Tumor angiogenesis and rectal carcinoma

Diseases of the Colon and Rectum
T J SaclaridesD B Rubin

Abstract

This study was designed to determine whether those rectal cancers that demonstrated increased vessel ingrowth or angiogenesis behave in a different fashion. The paraffin blocks of 48 rectal cancers removed by low anterior or abdominoperineal resection were recalled and immunostained with a monoclonal antibody specific for endothelial cell Factor VIII. The intense reddish brown color imparted to blood vessels facilitated their quantification which was undertaken at x100 and x200 magnification. Vessel counts within three microscopic fields were averaged and the relationships between angiogenesis score and tumor size, depth of invasion, incidence of lymph node or distant metastases, and survival were assessed. Significantly higher angiogenesis scores were seen in tumors with transmural penetration (at x100, P = 0.002; at x200, P = 0.002) and in patients dying before five years (at x100, P = 0.013; at x200, P = 0.034). Although higher angiogenesis scores were seen in patients with larger tumors and metastases, these trends were not statistically significant. Our results suggest that the growth of rectal cancer is dependent on the ingrowth of new blood vessels, and that increased vascularity promotes dissemination and adversely affe...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jan 1, 1985·Perspectives in Biology and Medicine·J Folkman

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Citations

Jul 1, 1996·The Journal of Pathology·S B FoxA L Harris
Sep 8, 1998·Seminars in Surgical Oncology·J M Jessup, M Loda
Oct 1, 1996·Diseases of the Colon and Rectum·S MooteriT Saclarides
Aug 10, 2002·American Journal of Surgery·Scott R SteeleRonald J Place
Oct 11, 2003·Urology·Toshiaki KinouchiKatsuhito Takahashi
Apr 12, 2003·Leukemia Research·Srdan VerstovsekMaher Albitar
Jun 28, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K HaustermansA C Begg
Feb 25, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G CoxK J O'Byrne
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y S ChungM Sowa
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Galindo GallegoA Aljama
Mar 15, 2001·Critical Reviews in Oncology/hematology·H H Sedlacek
Dec 6, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Reda S SaadJan F Silverman
May 1, 2000·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland· Heriot, Kumar
Feb 24, 2001·American Journal of Clinical Oncology·F TasE Topuz
Aug 8, 2006·American Journal of Clinical Oncology·Alexandra GiatromanolakiMichael I Koukourakis
Oct 13, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S E DuffG C Jayson
Sep 6, 2007·The Tohoku Journal of Experimental Medicine·Hong-Ling WangXiao-Yang Zhou
May 29, 2004·Virchows Archiv : an International Journal of Pathology·Femke VlemsHan van Krieken
Nov 6, 2009·Journal of Cancer Research and Clinical Oncology·Konstantinos DassoulasPetros Karakitsos
Sep 21, 2000·Pathology, Research and Practice·M Galindo-GallegoC López-Elzaurdia
Jun 11, 2008·Pathology, Research and Practice·Shahnawaz RasheedThomas Guenther
Nov 14, 2015·Pathology, Research and Practice·Luciano Delgado-PlasenciaVicente Medina-Arana
Sep 16, 2004·Seminars in Thoracic and Cardiovascular Surgery·Thomas A D'Amico
Mar 3, 2007·The Lancet Oncology·Vicky GohShahnawaz Rasheed
May 13, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M F AcikalinE Colak
Apr 16, 1998·Seminars in Radiation Oncology·J M JessupR Bleday
Feb 1, 1997·The Surgical Clinics of North America·T J Saclarides
May 16, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R RajaganeshanK R Prasad
Jan 23, 2003·Microscopy Research and Technique·Noriharu ShijuboNoriyuki Sato
Jan 16, 1999·Gynecologic Oncology·F QureshiS M Jacques
Nov 11, 2009·Gastroenterology Research and Practice·Rafael Uribarrena ARafael Uribarrena E

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