Tumor angiogenesis as a prognostic factor in cervical carcinoma

Gynecologic Oncology
D L WigginsP Calabresi

Abstract

Angiogenesis, the induction of new capillaries and venules, has been associated with tumor growth. Increased tumor size and new vessel growth may further the opportunity for tumor cells to enter the circulation and potentiate metastatic disease. To investigate if tumor angiogenesis could serve as a prognostic factor in cervical carcinoma, we counted microvessels (capillaries and venules) in 29 patients with squamous cell carcinoma of the cervix. Surgical specimens were stained for endothelial cells specifically with Factor VIII to identify all vessels. The microvessels were counted by light microscopy (per 200 x field) in tumor sections with the highest population of microvessels. This was performed by two investigators without knowledge of patient outcome or extent of disease. Microvessel counts in patients with squamous cell carcinoma were significantly different from those of control subjects: 56 +/- 28.9 and 16.3 +/- 3.3 (P = 0.013). There was no correlation between microvessel count and node status, parametrial involvement, depth of invasion, or gross disease. Microvessel count was significantly correlated with vascular space involvement (P = 0.017). Four patients who developed recurrent disease within 1 year had high micr...Continue Reading

Citations

Jun 20, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J MulleratC W Perrett
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H.-S. MoonB. H. Woo
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·O. Abulafia, D. M. Sherer
Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J L AlcázarG López-García
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D Cantu De LeónJ De La Garza Salazar
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A L Silva-FilhoJ R Cunha-Melo
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S TriratanachatN Jarurak
Mar 24, 1998·Annual Review of Medicine·B R Zetter
Jul 16, 2008·Journal of Cancer Research and Clinical Oncology·Petra L M ZusterzeelLeon F A G Massuger
Jul 1, 2008·Radiological Physics and Technology·Shohei MiyazakiTeruhito Mochizuki
May 21, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Pawan KumarPeter J Polverini
Apr 29, 2014·Histopathology·Alessandro PileriPier Paolo Piccaluga
Aug 15, 1997·Cancer·T KakuH Nakano
Jun 24, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Reda S SaadJan F Silverman
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·E A BossJ O Barentsz
Sep 28, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Francisco José Andreu-Martínez, Julia M Martínez-Mateu
Apr 9, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Juan Luis AlcázarGuillermo López-García
Nov 11, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Janice Matthews-GreerElba A Turbat-Herrera
Dec 6, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Reda S SaadJan F Silverman
Jan 27, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Shaira SahebaliJohannes J Bogers
Mar 31, 2016·The Oncologist·Jill K Alldredge, Krishnansu S Tewari
Sep 25, 2015·The Journal of Medical Investigation : JMI·Yasuyo SaijoMinoru Irahara
Apr 16, 2002·Clinical Orthopaedics and Related Research·Richard L McGoughRichard M Terek
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yu YuDes R Richardson
Jan 20, 2004·Cancer Research·Hao WangGerald A Soff
Oct 16, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Bahar Yetkin-ArikCornelis J F van Noorden
Feb 12, 2021·Microvascular Research·Yani P LatulJan-Paul W R Roovers
Feb 18, 1999·Gynecologic Oncology·O AbulafiaD M Sherer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.