PMID: 7539869Jul 1, 1995Paper

Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer

The Journal of Urology
T M JaegerP R Carroll

Abstract

Neovascularization of tumor tissue (tumor angiogenesis) is considered essential for tumor growth, proliferation and eventually metastasis. Microvessel density or count, a measure of tumor angiogenesis, correlates with clinical outcome in skin, breast, lung and prostate carcinomas. To determine whether an association of tumor angiogenesis and nodal metastasis exists in invasive bladder cancer, microvessel counts in 41 primary invasive stages (T2 to 4,NX,M0) bladder cancers were assessed. Microvessels were identified by immunostaining of endothelial cells for factor VIII-related antigen. Microvessels were scored in selected areas showing active neovascularization, either counting a 200 x field (0.74 mm.2) or by using a 10 x 10 square ocular grid (0.16 mm.2). The microvessel count correlated with the presence of occult lymph node metastases (p < 0.0001) by both techniques. The mean microvessel count in 27 patients without lymph node metastases was 56.2 microvessels per 200 x field (standard deviation [SD] 29.5, range 7 to 130) or 28.6 microvessels per grid (SD 14.4, range 4 to 65). The 14 patients with histologically proved lymph node metastases showed mean 138.1 microvessels per 200 x fields (SD 37.9, range 82 to 202) or 74.7 mic...Continue Reading

References

Jun 1, 1979·Cancer·G R ProutW U Shipley
Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S C CozadR Reymond
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Nov 1, 1989·Radiology·J E HusbandG R Cherryman
Jan 6, 1993·Journal of the National Cancer Institute·A S SarkisV E Reuter
Aug 21, 1993·Lancet·G DalbagniC Cordon-Cardo
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E Van HoefA M Schor

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Citations

Nov 20, 2004·Urological Research·Stephen G Williams, John P Stein
Nov 29, 2008·World Journal of Urology·Ramy F YoussefRichard J Cote
Aug 30, 2007·Cancer Metastasis Reviews·Peter C Black, Colin P N Dinney
Mar 24, 2005·International Urology and Nephrology·Ali CanoğluSümer Baltaci
Jun 1, 2011·International Urology and Nephrology·Eun ParkMoon Kee Chung
Apr 2, 2009·Current Oncology Reports·Aymen A Elfiky, Jonathan E Rosenberg
May 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johan BussinkAlbert J van der Kogel
Jan 1, 1997·Ultrasound in Medicine & Biology·S DelormeG van Kaick
Jul 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M L QuekJ P Stein
May 29, 2002·Surgical Oncology·Edward H Streeter, Adrian L Harris
Aug 6, 2003·Critical Reviews in Oncology/hematology·Sana Al-Sukhun, Maha Hussain
Jul 1, 1998·Urologic Oncology·Y FradetO Yoshida
Nov 20, 2010·Journal of the National Cancer Institute·Joong Sup ShimJun O Liu
Oct 1, 1996·The American Journal of Surgical Pathology·C J EngelF P O'Malley
Nov 21, 2000·Current Opinion in Oncology·D A Thomas, H M Kantarjian
Feb 28, 2008·The Cancer Journal·Jeanny B Aragon-Ching, William L Dahut
Jul 1, 2009·Therapeutic Advances in Medical Oncology·Guru SonpavdeJonathan E Rosenberg
Jan 24, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arjun V BalarDean F Bajorin
Dec 15, 2010·Future Oncology·Anthony KoupparisMartin E Gleave
Dec 21, 2013·International Journal of Oral Science·Wei-Peng JiangTie-Jun Li
Jan 6, 2010·Journal of Oncology·Biljana Culjkovic, Katherine L Borden
Jun 20, 2001·BJU International·J C GoddardR C Kockelbergh
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Sophia RanMichael G Rosenblum
Feb 21, 2008·Human Pathology·Liang ChengRodolfo Montironi
Jan 14, 2011·Immunopharmacology and Immunotoxicology·V Prabhu, C Guruvayoorappan
Dec 11, 1999·Cancer Investigation·M E Beckner
Sep 24, 2011·Journal of Oncology·Takuji TanakaKoji Suzuki
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Nov 6, 2013·Expert Opinion on Investigational Drugs·Francesc Pons, Joaquim Bellmunt
Nov 18, 2004·American Journal of Surgery·Krista A FrankenberryLinda C Vona-Davis
Jun 11, 2008·Pathology, Research and Practice·Shahnawaz RasheedThomas Guenther
Aug 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yair LotanArthur I Sagalowsky

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