PMID: 9558001Apr 29, 1998Paper

Tumor antigen presentation: changing the rules

Cancer Immunology, Immunotherapy : CII
T D ArmstrongS Ostrand-Rosenberg

Abstract

Cell-based tumor vaccines have been developed on the basis of the hypothesis that tumor cells can be genetically modified to present antigen to T lymphocytes directly. Contrary to expectations, cross-priming is the predominant pathway for activation of tumor-specific CD8+ T cells, while direct presentation of antigen dominates activation of tumor-specific CD4+ T cells. These results pose interesting paradoxes for the generation of immune responses, and have definite implications for the development of anti-cancer vaccines.

Citations

Jan 31, 2004·Gynecologic Oncology·Andrea FattorossiGiovanni Scambia
Mar 31, 2000·Trends in Biotechnology·M XuR E Humphreys
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M HanssonK Hellstrand
Jun 13, 2000·Cancer Biotherapy & Radiopharmaceuticals·M Hadzantonis, H O'Neill
Sep 4, 2003·The Cancer Journal·Duane A MitchellJohn H Sampson
Nov 24, 1999·Immunological Reviews·S Ostrand-RosenbergL A Hanyok
Jan 13, 2000·Immunological Reviews·J van BergenF Koning
Apr 29, 2008·Journal of Immune Based Therapies and Vaccines·Charles A GulloGerrard Teoh
Nov 13, 2001·Clinical and Experimental Immunology·R M GorczynskiJ Lei
Jul 1, 2008·Cancer Letters·Karim BennaceurJacques Portoukalian
Mar 6, 2015·National Science Review·Pengyuan YangXiao-Fan Wang
Jun 14, 2012·Cancer Immunology, Immunotherapy : CII·Pearline Zhaoying TeoJoseph A Mollick
Oct 25, 2011·Cancer Immunology, Immunotherapy : CII·Melisa J HamiltonKevin L Bennewith
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L QiS Ostrand-Rosenberg
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Connie JackamanDelia J Nelson
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Josette Péguet-NavarroJacques Portoukalian
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liqun LuoLieping Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.