Tumor antigens in astrocytic gliomas

Glia
S N KurpadD D Bigner

Abstract

Gliomas affect 15,000 to 17,000 Americans every year and carry a dismal prognosis. The potential of immunologically mediated diagnosis and therapy, although greatly enhanced since the advent of monoclonal antibodies, has not been fully realized due to significant problems, most especially the challenge of identifying antigenic molecules specific to glial tumors. Other problematic issues include antigen-associated factors such as heterogeneity, modulation, shedding, and cross-reactivity with normal cells, and factors associated with therapeutic agent delivery, typically variable tumor perfusion and unfavorable diffusional forces in tumor microenvironment. An understanding of these problems called for the delineation of operationally specific antigens (tumor-associated antigens not expressed by the normal central nervous system) combined with the use of compartmental therapeutic approaches to increase the specificity of therapy. Numerous antigens have been identified and are classified as extracellular/matrix-associated, membrane-associated, and intracellular antigens. Nevertheless, only a few have been demonstrated to be of significant therapeutic and diagnostic utility. These few include the extracellular matrix-associated anti...Continue Reading

References

Dec 28, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·O J Owens, R E Leake
Nov 1, 1992·Experimental Cell Research·R Asher, A Bignami
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J WongB Vogelstein
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M D PradosC B Wilson
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J EkstrandV P Collins
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P A HumphreyD D Bigner
Nov 1, 1991·The Journal of Cell Biology·J E Murphy-UllrichM Höök
Nov 1, 1991·Journal of Neuropathology and Experimental Neurology·C J WikstrandD D Bigner
Jul 1, 1991·Archives of Andrology·C ForestaC Scandellari
Jan 2, 1991·International Journal of Cancer. Journal International Du Cancer·A M AnderssonE Bock
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Jul 15, 1990·Cancer Genetics and Cytogenetics·S H BignerD D Bigner
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N SugawaV P Collins
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F S JonesG M Edelman
Sep 25, 1989·Biochimica Et Biophysica Acta·L SvennerholmB M Rynmark
Jan 1, 1987·Current Topics in Pathology. Ergebnisse Der Pathologie·P KleihuesR C Janzer
Jan 1, 1985·Journal of Cell Science. Supplement·G Carpenter
Nov 15, 1988·Cancer·C Daumas-DuportP Kelly
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J WongB Vogelstein
Nov 1, 1987·Cancer Genetics and Cytogenetics·S H BignerD D Bigner
Nov 14, 1986·Biochemical and Biophysical Research Communications·I C King, A C Sartorelli
Jan 1, 1986·European Journal of Nuclear Medicine·R B RichardsonH B Coakham
May 7, 1971·Brain Research·L F EngB Gerstl
Sep 1, 1983·Journal of Neuropathology and Experimental Neurology·J M BonninL J Rubinstein
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·I H PastanD D Bigner

❮ Previous
Next ❯

Citations

May 17, 2000·Journal of Biomedical Materials Research·D A EavaroneR V Bellamkonda
Jan 4, 1998·Seminars in Surgical Oncology·A Sehgal
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Christel Herold-MendeHans-Herbert Steiner
Feb 9, 2005·Brain Tumor Pathology·Ryo UedaMasahiro Toda
May 25, 2007·Cancer Immunology, Immunotherapy : CII·Justin T JordanAmy B Heimberger
Feb 14, 2009·Neurosurgical Review·Ryuya Yamanaka
Aug 26, 2010·Targeted Oncology·Mustafa Aziz HatibogluAmy B Heimberger
Oct 8, 1999·Pharmacology & Therapeutics·G M Dubowchik, M A Walker
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michelle A GhertSean P Scully
Apr 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Gwendalyn D KingPedro R Lowenstein
Oct 17, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kevin K H ChowStephen Gottschalk
Sep 4, 2003·The Cancer Journal·Duane A MitchellJohn H Sampson
Jul 7, 2001·The Journal of Small Animal Practice·O StigenA V Eggertsdottir
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun WeiAmy B Heimberger
Apr 14, 2000·Neurosurgery·I F ParneyK C Petruk
Jan 1, 2010·Pharmacogenomics and Personalized Medicine·Jing LiD Cory Adamson
Apr 7, 2009·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Ronald W MercerMaciej S Lesniak
Jan 5, 2002·Journal of Neurosurgery·M A ProescholdtE H Oldfield
Jul 11, 2013·Future Oncology·Vidyalakshmi ChandramohanDarell D Bigner
Dec 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dion A DanielsLarry Gold
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·Q R LuP M Black
Feb 5, 2005·Cancer Immunology, Immunotherapy : CII·Steven De VleeschouwerStefaan W Van Gool
Sep 29, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Steven De VleeschouwerFrank Van Calenbergh
Mar 9, 2012·Clinical & Developmental Immunology·Vidyalakshmi ChandramohanDarell D Bigner
Aug 28, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Ian F ParneyKenneth C Petruk
Oct 14, 2005·Expert Review of Anticancer Therapy·S Farzana Hussain, Amy B Heimberger
Jun 27, 2009·Expert Opinion on Investigational Drugs·Cory AdamsonDarell D Bigner
May 5, 2007·Expert Opinion on Biological Therapy·Ryuya Yamanaka, Kyogo Itoh
Sep 1, 2004·Expert Opinion on Biological Therapy·Abraham BoskovitzDarell D Bigner
Apr 12, 2008·Trends in Molecular Medicine·Ryuya Yamanaka
Sep 12, 2009·Brain Pathology·Stefaan Van GoolSteven De Vleeschouwer
Jul 12, 2005·Pediatric Blood & Cancer·Dennis P M HughesLaurence H Baker
Dec 31, 2003·Cellular Immunology·Maulik R Shah, William J Ramsey
Oct 4, 2005·Neurological Research·Christian W Sikorski, Maciej S Lesniak
May 27, 2004·Expert Opinion on Therapeutic Targets·Sabine MüllerManfred Westphal
Nov 24, 2016·Neurochemical Research·A R JayakumarM D Norenberg

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