Tumor-associated antigen 90K/Mac-2-binding protein: possible role in colon cancer

Journal of Cellular Biochemistry
Tricia A UlmerS Laferté

Abstract

The tumor-associated antigen 90K (TAA90K)/Mac-2-binding protein implicated in cancer progression and metastasis is modified by beta1-6 branched N-linked oligosaccharides in colon cancer cells, glycans shown to contribute to cancer metastasis. To elucidate the role of TAA90K in colon cancer, we examined its expression and function in human colon tumors and colon carcinoma cell lines. Immunohistochemical analyses of colon tumors revealed elevated expression of TAA90K in all samples analyzed compared to normal colon. To examine the function of TAA90K in colon cancer, we carried out protein and cell binding assays using TAA90K-His purified from HT-29 cells colon carcinoma cells infected with recombinant vaccinia virus expressing TAA90K containing a C-terminal poly-histidine tag. TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1. As expected, binding of TAA90K to galectin-3 was dependent on carbohydrate since it was inhibitable by lactose and asiolofetuin, and a TAA90K-His glycoform purified from HT-29 cells treated with the glycosylation inhibitor 1-deoxymannojirimycin bound poorly to galectin-3. Unlike TAA90K isolated from other cell types, TAA90K-H...Continue Reading

References

Jan 1, 1987·Methods in Enzymology·R K Merkle, R D Cummings
Nov 30, 1984·Biochemical and Biophysical Research Communications·J Bischoff, R Kornfeld
May 1, 1995·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·T J PowellL K Shawver
Dec 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S IacobelliA Chirianni
Jan 1, 1994·British Journal of Cancer·S IacobelliC Natoli
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·O FuscoS Iacobelli
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·M Trahey, I L Weissman
May 6, 1999·Cellular and Molecular Life Sciences : CMLS·G Reuter, H J Gabius
Jan 9, 2001·International Journal of Cancer. Journal International Du Cancer·N TinariF T Liu
Feb 28, 2002·The Journal of Biological Chemistry·Simon HellsternJürgen Engel
Sep 12, 2002·Biochimica Et Biophysica Acta·Gabriel A RabinovichMarta A Toscano
Nov 6, 2002·Biochimica Et Biophysica Acta·James W DennisMichael Demetriou
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
May 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hugues LegendreRobert Kiss
Mar 6, 2004·Cancer Metastasis Reviews·Yutaka Kondo, Jean-Pierre J Issa
Apr 30, 2004·Glycoconjugate Journal·Harald LahmHans-Joachim Gabius
Jun 3, 2004·Chembiochem : a European Journal of Chemical Biology·Hans-Joachim GabiusHarold Rüdiger
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Apr 22, 2005·Apoptosis : an International Journal on Programmed Cell Death·S NakaharaA Raz

❮ Previous
Next ❯

Citations

Jul 9, 2013·Enzyme and Microbial Technology·Kyoung Ro KimHyung Joon Cha
Dec 19, 2013·Disease Markers·Antonino GrassadoniaStefano Iacobelli
Feb 4, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·David ElashoffDavid T W Wong
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shen HuDavid T Wong
Sep 13, 2012·PloS One·Venktesh S ShirureMonica M Burdick
Nov 24, 2011·International Journal of Proteomics·Jianbo HeHelena R Chang
Oct 24, 2008·International Journal of Cancer. Journal International Du Cancer·Nicola TinariUNKNOWN Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO)
Apr 1, 2009·Proteomics. Clinical Applications·Hong JiRichard J Simpson
Jul 15, 2015·Journal of the American Chemical Society·Tzu-Wen LinChi-Huey Wong
Sep 27, 2016·Neoplasia : an International Journal for Oncology Research·So-Yeon ParkKyung Keun Kim
Jan 1, 2007·Proteomics. Clinical Applications·Hanna C DiehlIrmgard Schwarte-Waldhoff
Sep 1, 2007·Proteomics. Clinical Applications·Mark Aspinall-O'Dea, Eithne Costello
May 21, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Renate BeckerSven Christian
Dec 20, 2012·Experimental and Therapeutic Medicine·Jianxin HuXiuheng Liu
Sep 29, 2020·Frontiers in Oncology·Aysha FerdoushiHubert Hondermarck
Sep 28, 2021·Journal of Translational Medicine·Emily CaponeGianluca Sala

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.