PMID: 6164469Mar 15, 1981Paper

Tumor-associated antigens in polyps and carcinoma of the human large bowel

Cancer
J M Skinner, R Whitehead

Abstract

The presence of a number of tumor-associated antigens was studied in eight metaplastic polyps, 22 tubulovillous adenomas, and 20 carcinomas. Specific tumor antigens were identified using the immunohistochemical (P.A.P.) technique to detect carcinoembryonic antigen (CEA), human placental lactogen (HPL), alphafetoprotein (AFP), colon-specific antigen (CSA), pregnancy-specific beta lipoprotein 1 (SP1), human beta chorionic gonadotropin (beta hCG), and placental alkaline phosphatase (P Alk P), isoferritins (FE), and transferrin (TF). There is no difference in either the number of antigens present or the number of cases positive for each antigen in cancers and tubulovillous adenomas, but the majority of metaplastic polyps show only CEA and HPL positivity. The two metaplastic polyps showing a full range of positivity were atypical and over 5 mm in diameter. The findings have shown a remarkable similarity between polyps and cancer, which strengthens the concept of the relationship between adenomatous polyps and carcinoma of the colon.

References

Jan 1, 1979·Scandinavian Journal of Gastroenterology·B WahrenS Ingimarsson
May 1, 1979·Journal of Clinical Pathology·J O BeilbyC Parkinson
Sep 1, 1978·The Journal of Pathology·R C Curran, E L Jones
Jul 1, 1976·Journal of the National Cancer Institute·D M GoldenbergF J Primus
Dec 1, 1975·Cancer·T MutoB C Morson
Jan 1, 1974·Virchows Archiv. A, Pathological Anatomy and Histology·B WiebeckeM Eder
Nov 15, 1970·International Journal of Cancer. Journal International Du Cancer·F Martin, M S Martin

❮ Previous
Next ❯

Citations

Mar 10, 2001·International Journal of Cancer. Journal International Du Cancer·M LundinC Haglund
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·J M Skinner, R Whitehead
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·W D HaynesR Whitehead
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·J O Gebbers, J A Laissue
Jan 1, 1990·Digestive Diseases and Sciences·M V GrondinR D Gaskins
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W Fischbach, J Mössner
Jan 1, 1986·Sozial- Und Präventivmedizin·F J Gloor
Apr 1, 1983·Diseases of the Colon and Rectum·L NakopoulouN Papacharalampous
Jan 20, 2005·Diseases of the Colon and Rectum·Neil H HymanH Blasyk
Jan 1, 1985·Biochimica Et Biophysica Acta·J W ArendsJ Hilgers
Jul 4, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B J RembackenT Fujii
Oct 1, 1991·Scandinavian Journal of Gastroenterology·B VeressH Billing
Aug 1, 1996·Scandinavian Journal of Gastroenterology·H JørgensenL B Svendsen
Jan 28, 2009·Experimental and Molecular Pathology·Bradley G BrewerJohn W Eaton
Nov 29, 2005·Obstetrics and Gynecology Clinics of North America·Jeffrey C DunkelbergJohn Deutsch
Jul 1, 1983·European Journal of Cancer & Clinical Oncology·R Whitehead, J M Skinner
Mar 1, 1982·European Journal of Cancer & Clinical Oncology·J M Skinner, R Whitehead
May 15, 1983·International Journal of Cancer. Journal International Du Cancer·D StramignoniJ Schlom
Feb 1, 1983·The Journal of Pathology·J M SkinnerR Whitehead
Jan 28, 2006·Medical Hypotheses·Amir Harandi
Jan 10, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Hannah Krause, Anthony Watt
Jul 25, 2019·Frontiers in Immunology·Xiaoming OuyangJoseph C Wu
Jun 12, 2021·Stem Cell Reviews and Reports·Mojgan BaratiSeyedeh-Nafiseh Hassani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

© 2021 Meta ULC. All rights reserved