Tumor-associated expression of a serum protein, termed aX protein (alpha 1-inhibitor III), and its mRNA in rat liver

Japanese Journal of Cancer Research : Gann
K SugiyamaS Nagase

Abstract

A cDNA clone bearing the mRNA sequence for rat alpha X protein (alpha X) was isolated from a cDNA library constructed from rat liver mRNA. The nucleotide sequence of alpha X protein cDNA showed 97% homology with that of the 3'-proximal domain of alpha 1-inhibitor III cDNA. The amino acid sequence deduced from that of alpha X cDNA also exhibited high homology with the primary sequences of alpha 1-inhibitor III and alpha 2-macroglobulin. K231 ascites hepatoma cells were transplanted into male ACI rats, and the level of alpha X mRNA in the liver of the tumor-bearing rats was determined by RNA blot hybridization with the cDNA probe. The serum concentration of alpha X decreased to about 30% of the control value with time after transplantation. The amount of alpha X mRNA in the liver of tumor-bearing rats was proportional to the serum concentration of alpha X. The serum concentrations of transferrin and albumin in the tumor-bearing rats also decreased to about 30 and 60% of the normal levels, respectively. However, the amounts of mRNAs for transferrin and albumin in the liver of tumor-bearing rats did not decrease. These findings indicate that the mechanisms of tumor-associated decrease in the concentrations of different serum protei...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D KioussisJ M Taylor
Nov 1, 1987·Journal of Biochemistry·K SugiyamaS Nagase
Aug 15, 1967·Biochimica Et Biophysica Acta·J O Jeppsson
Jul 1, 1983·Jikken dobutsu. Experimental animals·T EmoriS Nagase
Oct 1, 1982·Experimental and Molecular Pathology·R N Weiner, M Reinacher
Jan 1, 1960·The Biochemical Journal·P N CAMPBELLB A KERNOT

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