Tumor-Associated Glycans and Immune Surveillance

Vaccines
Behjatolah Monzavi-KarbassiThomas Kieber-Emmons

Abstract

Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that bridge innate immune surveillance and adaptive antitumor immunity in clinical applications. T-cells, being a part of the adaptive immune response, are the most popular component of the immune system considered for targeting tumor cells. However, for TACAs, T-cells take a back seat to antibodies and natural killer cells as first-line innate defense mechanisms. Here, we briefly highlight the rationale associated with the relative importance of the immune surveillance machinery that might be applicable for developing therapeutics.

References

Feb 1, 1991·Experimental Cell Research·I VanderElst, J W Dennis
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R F Irie, D L Morton
Aug 1, 1972·The Journal of Experimental Medicine·N R Klinman
Jan 1, 1970·Progress in Experimental Tumor Research·F M Burnet
Jul 1, 1995·The Journal of Experimental Medicine·X J Zhao, N K Cheung
May 24, 1996·Biochimica Et Biophysica Acta·L A Valentino, S Ladisch
Jan 1, 1997·Glycoconjugate Journal·M S SandrinI F McKenzie
Jul 1, 1997·Scandinavian Journal of Immunology·C M BöhmC Hanski
Nov 14, 1997·Cancer Immunology, Immunotherapy : CII·P O LivingstonK O Lloyd
Oct 6, 1997·Glycobiology·F R Carbone, P A Gleeson
Jul 17, 1998·Current Opinion in Chemical Biology·K J Yarema, C R Bertozzi
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E C HsuehD L Morton
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N K CheungS M Larson
Feb 16, 1999·The Journal of Investigative Dermatology·T TakahashiR F Irie
Oct 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C CostaW L Fodor
Mar 4, 2000·The Journal of Biological Chemistry·A O TzianabosD L Kasper
Apr 5, 2000·The Journal of Biological Chemistry·P LuoT Kieber-Emmons
Jan 3, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Tsuboi, M Fukuda
Mar 3, 2001·Current Opinion in Immunology·M J Soloski
Mar 28, 2001·Science·C R Bertozzi, L L Kiessling
Jun 8, 2001·International Journal of Cancer. Journal International Du Cancer·F G SnijdewintP Kenemans
Oct 25, 2001·International Immunology·B Monzavi-KarbassiT Kieber-Emmons
Apr 12, 2002·Trends in Biotechnology·Behjatolah Monzavi-KarbassiThomas Kieber-Emmons
Jun 7, 2002·IUBMB Life·Christof R HauckDavid D Schlaepfer
Sep 10, 2002·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Günter Butschak, Uwe Karsten
Nov 6, 2002·Biochimica Et Biophysica Acta·Minoru Fukuda

❮ Previous
Next ❯

Citations

Feb 20, 2016·ACS Chemical Biology·Danyang FengFengshan Wang
Mar 26, 2016·Frontiers in Oncology·Ana Flávia Fernandes Ribas NardyAlexandre Morrot
Mar 10, 2016·Organic & Biomolecular Chemistry·Kevin R TrabbicPeter R Andreana
Jul 23, 2015·ACS Applied Materials & Interfaces·Suttipun SungsuwanXuefei Huang
Aug 28, 2016·Biochimica Et Biophysica Acta. General Subjects·Dorota Hoja-ŁukowiczMonika Bubka
Dec 9, 2016·Human Vaccines & Immunotherapeutics·Shina PashovaAnastas Pashov
May 12, 2017·Human Vaccines & Immunotherapeutics·Abdolkarim Sheikhi, Abdollah Jafarzadeh
Apr 12, 2018·Diagnostics·Keun-Yeong JeongHwan Mook Kim
Mar 8, 2018·Medicinal Research Reviews·Meng-Man WeiXin-Shan Ye
Jun 26, 2018·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Anastas PashovThomas Kieber-Emmons
Jun 13, 2018·Biological Chemistry·Amanda P B AlbuquerqueEduardo I C Beltrão
Aug 15, 2018·BioMed Research International·Oleg KurtenkovKersti Klaamas
Aug 29, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Mona O MohsenMartin F Bachmann
Jun 15, 2018·Breast Cancer : Basic and Clinical Research·Issam MakhoulThomas Kieber-Emmons
Nov 20, 2016·Cancer Immunology Research·Marcela A HaroKaren M Haas
Jan 14, 2020·Seminars in Immunology·Donella M Beckwith, Maré Cudic

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
glycotransferases
biopsy
xenografts
xenograft
transgenic
transgenics

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Journal of Oral Pathology
E Dabelsteen, H Clausen
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
S von Kleist
© 2021 Meta ULC. All rights reserved