Tumor-associated macrophages and crown-like structures in adipose tissue in breast cancer

Breast Cancer Research and Treatment
Yoon Jin ChaJa Seung Koo

Abstract

We aimed to evaluate macrophage infiltration and to identify the status of crown-like structures (CLSs) in mammary adipose tissue of human breast tissue in cases with and without breast cancer. Breast adipose tissue was obtained from reduction mammoplasty (N = 56, Group 1), non-neoplastic breast tissue of breast cancer patients (N = 84, Group 2), and breast cancer with adipose stroma (N = 140, Group 3). Immunohistochemical staining of CD68 and CD163 was performed, and the infiltrating macrophages and CLSs within breast adipose tissue were evaluated. Group 3 had the largest number of CD68-positive (CD68+) and CD163-positive (CD163+) macrophages and CLSs within adipose tissue (P < 0.001). Among Group 3, cases with high levels of CD68+ and CD163+ macrophages commonly had a higher histologic grade (P = 0.016 and P = 0.045), and cases with CD163+ CLSs were correlated with old age (P = 0.042), estrogen receptor negativity (P = 0.013), human epidermal growth factor receptor-2 positivity (P = 0.043), and non-luminal A type (P = 0.039). Upon univariate analysis, high levels of CD163+ macrophages were associated with shorter disease-free survival in node-negative breast cancer patients (P = 0.033), and CD68+ CLSs were associated with sho...Continue Reading

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Citations

Aug 14, 2020·Journal of Experimental & Clinical Cancer Research : CR·Chongru ZhaoYiping Wu
Jul 15, 2020·International Journal of Molecular Sciences·Michele MannelliTania Fiaschi
May 1, 2019·International Journal of Molecular Sciences·Yoon Jin Cha, Ja Seung Koo
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Jan 9, 2021·Biomarker Research·Qi WuShengrong Sun
Apr 4, 2021·International Journal of Environmental Research and Public Health·Robert MujkićKristina Selthofer-Relatić
Oct 23, 2021·Molecular Medicine Reports·Huihui Yao, Songbing He

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