Tumor-associated macrophages as targets for tumor immunotherapy

Immunotherapy
Andreas WeigertBernhard Brüne

Abstract

Restoration of one of the major physiological functions of the body's immune response, the rejection of malignant cells, is a promising yet challenging task for cancer therapy. Prinicipally, immunotherapeutic approaches make use of cells of the adaptive immune system, since antigen-based tumor rejection might be the most specific approach. However, other immune cell populations, such as tumor-associated macrophages (TAMs), contribute significantly to protumor mechanisms elicited by a distorted immune response. In this review, we summarize the current knowledge about the pathology of TAMs and discuss potential therapeutic approaches to overcome TAM-mediated tumor promotion. Hereby, we focus on TAM phenotypes that were observed in the clinically relevant stages of cancer progression. The function of macrophages and other inflammatory cells in the onset of cancer has been discussed elsewhere.

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Citations

Apr 2, 2009·Biological Chemistry·Andreas WeigertBernhard Brüne
Oct 4, 2013·Immunotherapy·Roheena Z PanniDavid G DeNardo
Oct 10, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Joao Paulo Mattos AlmeidaRebekah Anna Drezek
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Nov 2, 2012·Immunology·Xiaoqiang TangHengyi Xiao
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Jul 12, 2016·Antioxidants & Redox Signaling·Bernhard BrüneAndreas Weigert
Nov 2, 2016·Expert Opinion on Biological Therapy·Elham Beyranvand NejadSjoerd H van der Burg
May 17, 2017·Advanced Drug Delivery Reviews·Ayelet David
Nov 27, 2019·Cells·Shahzad Nawaz SyedBernhard Brüne
May 19, 2016·Oncotarget·Ran CuiXiang-Lin Tan
Apr 26, 2017·Oncology Reports·Takahisa YamaguchiTetsuo Ohta
Apr 2, 2019·Journal of Immunology Research·M A F YahayaN A R Nik Mohd Afizan
Aug 15, 2017·Mediators of Inflammation·Shahzad N SyedBernhard Brüne

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Methods Mentioned

BETA
nuclear translocation
xenografts
transgenic
antisense
xenograft

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