Tumor-Associated Macrophages (TAM) are recruited to the aging prostate epithelial lesions and become intermingled with basal cells.

Andrology
Hipácia Werneck-GomesCleida A Oliveira

Abstract

Prostate cancer remains one of the most common cancers in men. Macrophages are thought to be important regulators in cancers, and their potential involvement in prostate cancer should not be overlooked. Therefore, the association between macrophages and the pre-tumorous changes in prostate epithelium during aging deserves further investigation. We sought to investigate whether macrophages would be recruited into the prostate epithelium that display pathological lesions commonly found during aging. Prostates of aging rats, with and without treatment with a combination of testosterone and estradiol, were examined for premalignant and malignant epithelial lesions. For comparison, prostates of castrated rats were also investigated. Intraepithelial macrophages were found restricted to areas of premalignant and malignant lesions. An unprecedented interaction between macrophages and basal cells was observed in the aging pathological lesions. The intraepithelial macrophages were associated with autophagy, in contrast to those found after castration. In prostate lesions, the intraepithelial macrophages had TAM phenotype (CD68+/iNOS+/CD206+/ARG+), denoting a possible involvement in cancer progression. However, M2 macrophages (CD68+/CD163...Continue Reading

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Citations

Feb 3, 2021·International Journal of Molecular Sciences·Manuel WeberFalk Wehrhan
Nov 13, 2020·Chinese Medical Journal·Shao-Dan LiuYong-Xiang Zhao
Aug 20, 2021·Scientific Reports·Menka KhoobchandaniKattesh V Katti

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