PMID: 49053Jun 1, 1975Paper

Tumor-associated transplantation antigens in immune rejection of mouse malignant cell hybrids

Proceedings of the National Academy of Sciences of the United States of America
J Jami, E Ritz

Abstract

The inability of mouse cell hybrids derived from two malignant parental cells to produce tumors in syngeneic F1 hosts was analyzed. YC hybrids, derived from the fusion of C1.1D and L1210 clls, failed to induce any tumor in adult mice, while 91% of x-irradiated newborn mice developed tumors and died. Some telocentric chromosomes were lacking in hybrid tumors; however, none of the immunologically intact adult mice developed tumors when grafted with tumors grown in x-irradiated newborn mice. This indicates that histocompatibility factors interfered in the failure of YC tumors to grow to adult hosts. Syngeneic F1 mice immunized with Y2C hybrid cells had cytotoxic antibodies against Y2C hybrids and C1.1D and L1210 parental cells. Complete absorption of cytotoxic antibodies directed against hybrid cells by mixtures of both parental cell lines demonstrates the absence of any new antigen on hybrid cells.Hyb rid cells had a higher density of C1.1D-tumor antigenic sites, as compared to C1.1D parental cells. This possibly explains the higher antigenicity and/or the higher sensitivity to immune lysis of hybrid cells.

References

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Citations

Aug 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu T Aleksanian, T N Ignatova
May 1, 1985·European Journal of Cancer & Clinical Oncology·D R WangE P Cohen
Mar 4, 1976·Nature·E J Stanbridge
Oct 15, 1983·International Journal of Cancer. Journal International Du Cancer·K KawashimaK Kojima
Aug 16, 1976·European Journal of Pediatrics·H Müller, G R Stalder
Jun 15, 1981·International Journal of Cancer. Journal International Du Cancer·B PayelleG Lespinats
Feb 1, 1982·Molecular and Cellular Biology·N Bouck, G di Mayorca

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