Tumor bed boost omission after negative re-excision in breast-conservation treatment

Annals of Surgical Oncology
Douglas W ArthurDavid E Wazer

Abstract

We evaluated the necessity of a tumor bed boost after whole-breast radiotherapy for early-stage breast cancer after breast-conserving surgery and negative re-excision. Of patients treated at the Virginia Commonwealth and Tufts Universities with breast-conservation therapy for early-stage breast cancer between 1983 and 1999, 205 required re-excision of the tumor cavity to obtain clear margins and were found to be without residual disease. Adjuvant conventionally fractionated whole-breast radiotherapy was given to a total dose of 50 Gy in 25 fractions. The tumor bed boost was omitted. The median follow-up was 98 months (range, 6-229 months). The tumor histological diagnosis was primarily infiltrating ductal carcinoma (183 cases; 89%). Nodal involvement was documented in 49 cases (24%). There were four documented recurrences at the tumor bed site. Five in-breast recurrences were documented to be in a location removed from the tumor bed. The overall Kaplan-Meier 15-year in-breast control rate was 92.4%, and the freedom from true recurrence rate was 97.6%. The findings support the concept that postlumpectomy radiotherapy can be tailored according to the degree of surgical resection. There is an easily identifiable subgroup of patien...Continue Reading

References

Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·A Recht, J R Harris
Mar 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R GelmanJ R Harris
Feb 21, 1990·Journal of the National Cancer Institute·UNKNOWN Uppsala-Orebro Breast Cancer Study Group
Oct 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R Schmidt-UllrichN J Robert
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·A RechtJ R Harris
Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·W F Regine, C A Kramer
Dec 1, 1994·International Journal of Radiation Oncology, Biology, Physics·R D Pezner
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·G De PaloP Boracchi
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P RomestaingJ P Gérard
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D E WazerR Graham
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·D E WazerJ K Erban
Jan 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A HaymanJ C Weeks
Jun 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E ObedianB G Haffty
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U VeronesiR Zucali
Jan 17, 2002·The New England Journal of Medicine·H BartelinkUNKNOWN European Organization for Research and Treatment of Cancer Radiotherapy and Breast Cancer Groups
Oct 24, 2002·The New England Journal of Medicine·Monica Morrow
Nov 12, 2002·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Csaba PolgárGyörgy Németh

❮ Previous
Next ❯

Citations

Jan 2, 2010·International Journal of Radiation Oncology, Biology, Physics·Mark TrombettaDavid Parda
Apr 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Lorenzo LiviGiampaolo Biti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Lorenzo LiviGiampaolo P Biti
The New England Journal of Medicine
H BartelinkEuropean Organization for Research and Treatment of Cancer Radiotherapy and Breast Cancer Groups
Journal of the National Cancer Institute
Frank A ViciniAlvaro A Martinez
International Journal of Radiation Oncology, Biology, Physics
Richard PötterAustrian Breast and Colorectal Cancer Study Group
© 2022 Meta ULC. All rights reserved