PMID: 2912935Jan 1, 1989Paper

Tumor bed effect-induced reduction of tumor radiocurability through the increase in hypoxic cell fraction

International Journal of Radiation Oncology, Biology, Physics
Luka MilasL J Peters

Abstract

Two murine tumors, designated FSA and SA-NH, that exhibit strong tumor bed effect (TBE), were found to be less radiocurable if they grew in the preirradiated s.c. tissue. Tumors were transplanted into the right thighs irradiated with 30 Gy one day earlier, and were irradiated when they grew to 6 mm. The TBE-caused reduction in tumor radiocurability was manifested by the increase in TCD50 values. Tumor irradiation under hypoxic conditions increased TCD50 values less, and the hypoxic cell radiosensitizer misonidazole reduced TCD50 values more, when tumors grew in preirradiated than when they grew in unirradiated legs. This implies that TBE-induced increase in TCD50 was due to increase in hypoxic fraction of tumor cells. For 6 mm SA-NH tumor the estimated increase in hypoxic cell fraction was from the control value of 3% to 12%. Thus, TBE causes the reduction in tumor radiocurability through the increase in hypoxic fraction of tumor cells.

Citations

Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·H P Beck-Bornholdt
Oct 1, 1990·International Journal of Radiation Oncology, Biology, Physics·F KallinowskiP Vaupel
Oct 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·N MirkovicL Milas
Aug 22, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Oliver RiestererLuka Milas
Mar 25, 2018·Basic & Clinical Pharmacology & Toxicology·Ales GroseljGregor Sersa
Mar 30, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A NivetF Huguet

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