[Tumor biology of oropharyngeal carcinoma].

HNO
S LabanT K Hoffmann

Abstract

Etiologically, oropharyngeal squamous cell carcinoma (OPSCC) can be divided into OPSCC caused by noxious agents and human papillomavirus (HPV)-driven carcinoma. These types differ with regard to clinical features and prognosis-differences which are rooted in the underlying molecular biology of the tumor. The aim of this work is to provide an overview of the molecular biological characteristics of the genetics, epigenetics, and immunology of OPSCC. A literature review was performed on a selection of genetic, epigenetic, and immunological factors characterizing OPSCC. The understanding of genetic aberrations and their consequences for cancerogenesis and tumor biology is increasing. Epigenetic phenomena are complementing functional relationships. However, epigenetic mechanisms of gene regulation are complex and much research is still required in this field. Immunological aspects of cancer molecular biology have moved into the focus in light of recent advances in the field of immunotherapy. The tumor biology of OPSCC is primarily defined by its HPV status. Additionally, HPV-independent genetic, epigenetic, and immunological signatures are being defined. From these advances, rationales for new treatment concepts may evolve.

References

Mar 15, 1979·Nature·D P Lane, L V Crawford
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A B DeLeoL J Old
May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
Nov 15, 2005·International Journal of Cancer. Journal International Du Cancer·Thomas K HoffmannTheresa L Whiteside
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wanglong QiuGloria H Su
Dec 21, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa LicitraSilvana Pilotti
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
Oct 25, 2011·International Journal of Cancer. Journal International Du Cancer·M HeusinkveldS H van der Burg
Dec 21, 2011·The Laryngoscope·Derrick WansomUNKNOWN UM Head Neck SPORE Program
Mar 16, 2013·Clinical Oral Investigations·Henning HankenMarco Blessmann
Apr 11, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cecilia NordforsTina Dalianis
May 3, 2013·The Journal of Clinical Investigation·Efterpi KostareliJochen Hess
Jul 16, 2013·Nature Genetics·Michael B BurnsReuben S Harris
Jul 31, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roberto A LlerasThomas J Belbin
Aug 13, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·B KoflerR Knecht
Oct 31, 2013·British Journal of Cancer·M J WardG J Thomas
Apr 9, 2014·Oncoimmunology·Panagiotis BalermpasEmmanouil Fokas
Jul 25, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tanguy Y SeiwertPeter S Hammerman
Jan 13, 2015·BMC Infectious Diseases·Karl T KelseyMichael McClean
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
Dec 15, 2015·International Journal of Cancer. Journal International Du Cancer·Steffen WagnerJens Peter Klussmann
Jan 21, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Efterpi KostareliJochen Hess
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
Nov 1, 2016·Nature Reviews. Genetics·Cameron P BrackenGregory J Goodall
Nov 20, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ankur ChakravarthyTim R Fenton
Jan 10, 2017·Nature Genetics·Simon Papillon-CavanaghNada Jabado
Jul 18, 2017·Frontiers in Oncology·Nora WürdemannClaus Wittekindt
Sep 28, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Oliver WoodChristian H Ottensmeier
Oct 12, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marij J P WeltersSjoerd H van der Burg
Nov 22, 2017·International Journal of Cancer. Journal International Du Cancer·Lea SchroederDana Holzinger
Jan 15, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C DubotI Bieche

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