Tumor budding and poorly-differentiated cluster in prognostication in Stage II colon cancer

Pathology, Research and Practice
Victor Wai Kwan Lee, Kui Fat Chan

Abstract

Comparison between tumor budding (TB) and poorly-differentiated clusters (PDC) for prognostication in Stage II colon cancer was not extensively studied in literature. In this retrospective study, we assessed TB (according to the consensus statement in 2016) and PDC in 135 Stage II colon adenocarcinoma resection specimens. Counting of TB and PDC was performed on H&E slides. High-grade TB (Bd3 (≥10 tumor buds in 0.785 mm2)) and high-grade PDC (Grade 3 (≥10)) were found in 20% and 17% of cases respectively. High-grade TB was associated with pT4 (p = 0.008) and presence of lymphovascular invasion (p = 0.001). There was correlation between TB and PDC grades (p < 0.001), in which both grades were the same or one grade apart in majority of the cases (95%). Both TB and PDC correlated with 5-year disease-specific survival (DSS) and overall survival (OS) (DSS for TB: 89% (Bd1); 73% (Bd2); 52% (Bd3), p = 0.001) (DSS for PDC: 88% (Grade 1); 72% (Grade 2); 61% (Grade 3), p = 0.021). Survival curves of Stage II colon cancer could be further stratified by TB and PDC (log-rank tests: TB p < 0.001; PDC p = 0.009). Combining TB and PDC grades into single grading system (high-grade: Bd3 + G2, Bd2 + G3, Bd3 + G3; low-grade: other combinations) was...Continue Reading

Citations

Sep 10, 2020·Nature Reviews. Clinical Oncology·Alessandro LugliIris D Nagtegaal
Mar 11, 2019·Pathology Oncology Research : POR·M J Fernández-AceñeroA Cebrián
Mar 28, 2019·International Journal of Colorectal Disease·Adriana RomitiEmanuela Pilozzi
Jul 4, 2020·Pathology Oncology Research : POR·Gorana AralicaPaško Konjevoda
Jun 25, 2020·Virchows Archiv : an International Journal of Pathology·Serena AmmendolaValeria Barresi
Jul 6, 2020·Cancer Treatment Reviews·Pauline ParentAnthony Turpin
Apr 22, 2021·International Journal of Clinical Oncology·Shintaro AkabaneHideki Ohdan
Aug 28, 2021·The Journal of Obstetrics and Gynaecology Research·Megumi YamamotoToru Tsuchida

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