Tumor burden evaluation in NF1 patients with plexiform neurofibromas in daily clinical practice

Acta neurochirurgica
Li-tal PrattL Ben-Sira

Abstract

Existing volumetric measurements of plexiform neurofibromas (PNs) are time consuming and error prone, as they require delineation of PN boundaries, a procedure that is not practical in the typical clinical setting. The aim of this study is to assess the Plexiform Neurofibroma Instant Segmentation Tool (PNist), a novel semi-automated segmentation program that we developed for PN delineation in a clinical context. PNist was designed to greatly simplify volumetric assessment of PNs through use of an intuitive user interface while providing objectively consistent results with minimal interobserver and intraobserver variabilities in reasonable time. PNs were measured in 30 magnetic resonance imaging (MRI) scans from 12 patients with neurofibromatosis 1. Volumetric measurements were performed using PNist and compared to a standard semi-automated volumetric method (Analyze 9.0). High correlation was detected between PNist and the semi-automated method (R(2) = 0.996), with a mean volume overlap error of 9.54 % and low intraobserver and interobserver variabilities. The segmentation time required for PNist was 60 % of the time required for Analyze 9.0 (360 versus 900 s, respectively). PNist was also reliable when assessing changes in tum...Continue Reading

References

Jan 11, 1991·Skeletal Radiology·M A StullM C Nelson
Jan 1, 1991·Magnetic Resonance Imaging·P R Ros, N Eshaghi
Jan 24, 2003·AJR. American Journal of Roentgenology·Tina Young PoussaintBruce Korf
Jul 14, 2004·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Jeffrey SolomonBrigitte Widemann
Jun 19, 2008·Neuro-oncology·Victor-F MautnerJan M Friedman
Oct 22, 2008·Journal of Medical Genetics·T TuckerV-F Mautner
Dec 19, 2008·European Journal of Radiology·S F L Van MeerbeeckG Mortier
Jan 2, 2009·Pediatrics·Virginia C WilliamsBernard L Maria
Jun 19, 2012·Medical & Biological Engineering & Computing·Lior WeizmanLiat Ben Sira
Oct 6, 2012·Orphanet Journal of Rare Diseases·Rosa NguyenVictor-Felix Mautner
Nov 21, 2013·International Journal of Computer Assisted Radiology and Surgery·Lior WeizmanLiat Ben Sira

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Citations

Jun 22, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ben ShoftyShlomi Constantini

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