PMID: 2096989Dec 1, 1990Paper

Tumor cell adhesion to frozen lymph node sections--a correlate of lymphatic metastasis in breast carcinoma models of human and rat origin

Breast Cancer Research and Treatment
P BrodtH Shibata

Abstract

The role of tumor cell adhesion in lymphatic metastasis of breast cancer was investigated in vitro using a rat mammary carcinoma model of four cell lines with different metastatic phenotypes, two human breast cancer cell lines, and cryostast sections of normal rat or human lymph nodes, respectively. A positive correlation was found between the adhesion levels obtained with three metastatic rat mammary cell lines (TMT-081 greater than MT-100M & TMT-50) and a non-metastatic line MT-W9B, the latter being 3-4 fold less adhesive to the lymph node sections than the metastatic tumors. This selective adhesion was specific, as it was not found with cryostat sections of rat liver and brain. Enzyme assays indicated that cell surface glycoproteins bearing terminal beta-galactoside residues were involved in the adhesion of the rat tumors. Adhesion of the human breast carcinoma cells Hs578T to sections of human lymph nodes was significantly higher than that of the normal breast epithelial cell line Hs578Bst, and comparable to adhesion of a second breast carcinoma line, MCF-7. Moreover, Hs578T cells isolated from regional lymph nodes of tumor-bearing nude mice were significantly more adhesive to human lymph node sections than the parental lin...Continue Reading

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Citations

May 29, 1996·International Journal of Cancer. Journal International Du Cancer·N J TawilP Brodt
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Christina LeBedisPnina Brodt
May 1, 1991·Cancer Metastasis Reviews·P Brodt
Jan 5, 2001·The Surgical Clinics of North America·J E GervasoniB Cady
Aug 1, 1993·Cell Biophysics·R M LafrenieF W Orr
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·M Schirner, M R Schneider
Aug 19, 2011·FEBS Letters·Abhik Saha, Erle S Robertson
Jul 14, 2017·PloS One·María Jiménez-GonzálezTorsten Reese
Jun 1, 1991·Cancer Metastasis Reviews·I R HartJ F Marshall
Nov 19, 2004·Cancer Research·Hiroshi NagataToshifumi Hibi

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