Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

Cancer Research
Tareq SalehDavid A Gewirtz

Abstract

Senescence, a durable form of growth arrest, represents a primary response to numerous anticancer therapies. Although the paradigm that senescence is "irreversible" has largely withstood the findings of tumor cell recovery from what has been termed "pseudo-senescence" or "senescence-like arrest," a review of the literature suggests that therapy-induced senescence in tumor cells is not obligatorily a permanent cell fate. Consequently, we propose that senescence represents one avenue whereby tumor cells evade the direct cytotoxic impact of therapy, thereby allowing for prolonged survival in a dormant state, with the potential to recover self-renewal capacity and contribute to disease recurrence.

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Citations

Jul 4, 2020·Carcinogenesis·Jessica BeckCurtis Harris
Feb 8, 2020·Cells·Francisco Triana-MartínezEduardo Domínguez
Aug 26, 2020·Metabolites·Alec Millner, G Ekin Atilla-Gokcumen
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Aug 17, 2020·International Journal of Molecular Sciences·David Murray, Razmik Mirzayans
Aug 28, 2020·Radiation Research·Nipa H PatelDavid A Gewirtz
Aug 14, 2019·Cancer Letters·Olivier PluquetOlivier Coqueret
Jan 27, 2021·Cells·Dilara DemirciSerif Senturk
Dec 29, 2020·Seminars in Cancer Biology·Tareq SalehDavid A Gewirtz
Dec 31, 2020·Neuropathology and Applied Neurobiology·Gabriela CarrenoJuan Pedro Martinez-Barbera
Jan 29, 2021·Proceedings of the National Academy of Sciences of the United States of America·K J PientaR M Axelrod
Dec 3, 2020·International Journal of Molecular Sciences·Razmik Mirzayans, David Murray
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