Tumor-cell number and viability as quality and efficacy parameters of autologous virus-modified cancer vaccines in patients with breast or ovarian cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
T AhlertV Schirrmacher

Abstract

We investigated quality and efficacy criteria of an autologous, physically and immunologically purified, Newcastle disease virus (NDV)-modified, irradiated tumor-cell vaccine (ATV-NDV) by analyzing three independent cohorts (a through c) of patients vaccinated between 1991 and 1995. Included were 63 patients with primary breast cancer (a), 27 with metastatic pretreated breast cancer (b), and 31 with metastatic pretreated ovarian cancer (c). In addition to vaccine, cohorts b and c received nonspecific immunotherapy as supportive treatment. After cryoconservation and purification, the vaccines varied in applied numbers of viable cells and dead cell contaminations. We retrospectively hypothesized that an immunogenic vaccine should contain at least 1.5 x 10(6) viable tumor cells and viability should be at least 33%. Each cohort was thus divided into two groups; one that received vaccine type A (A), fulfilling both criteria; and the other type B (B), missing one or both criteria. Conventional prognostic factors were wall balanced between A and B in cohorts a and c. In cohort a, there was a benefit in survival (P = .026) and disease-free survival (P = .089) for A. In addition, in cohort a, the relative risk of dying in the group that...Continue Reading

Citations

Sep 29, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans Herbert SteinerChristel Herold-Mende
Aug 19, 2005·International Journal of Cancer. Journal International Du Cancer·Claudia HaasVolker Schirrmacher
Dec 1, 2006·Annals of the New York Academy of Sciences·Zhiliang WangJiming Chen
Dec 2, 2011·Journal of Biomedicine & Biotechnology·Han Yuen LamNoorjahan Banu Alitheen
Oct 24, 2018·Breast Cancer Research : BCR·Sruthi RavindranathanDavid A Zaharoff
Jul 30, 2005·Expert Opinion on Biological Therapy·Volker Schirrmacher
Apr 10, 2009·Cancer Investigation·Karen S Anderson
Sep 26, 2007·Expert Review of Anticancer Therapy·Giuseppe CuriglianoAron Goldhirsch
Dec 20, 2008·Expert Review of Vaccines·Philippe Fournier, Volker Schirrmacher
Oct 14, 2014·Expert Review of Vaccines·Samantha L KurtzDavid A Zaharoff
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P J CozziY Fong
Dec 18, 2004·Cancer Gene Therapy·Huijie BianVolker Schirrmacher
Jun 12, 2009·Journal of Virology·Mostafa JarahianFrank Momburg
Mar 8, 2012·Future Microbiology·Dmitriy Zamarin, Peter Palese
May 12, 2011·International Reviews of Immunology·Cheryl Lai-Lai ChiangGeorge Coukos
Jan 1, 2013·Biology·Philippe Fournier, Volker Schirrmacher
Sep 3, 2017·Medical Oncology·Mai Takamura-IshiiKatsuro Hagiwara
Jun 13, 2017·Expert Opinion on Biological Therapy·Antonela S AsadMarianela Candolfi
Feb 14, 2006·International Journal of Cancer. Journal International Du Cancer·Christoph FiolaVolker Schirrmacher
Apr 25, 2014·Expert Review of Vaccines·Laetitia CiccheleroNiek N Sanders
Dec 24, 2005·Expert Review of Vaccines·Leisha A Emens
Apr 8, 2010·Expert Review of Vaccines·Volker Schirrmacher, Philippe Fournier
Jul 29, 2020·Biomedicines·Volker SchirrmacherStefaan W Van Gool
Sep 13, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kathy MatuszewskaJim Petrik
Jan 1, 2020·Molecular Therapy Oncolytics·Chase Burton, Eric Bartee
Dec 3, 2020·Cancers·Bharat BurmanDmitriy Zamarin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Acute Disseminated Encephalomyelitis

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system. Discover the latest research on acute disseminated encephalomyelitis here.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.