Tumor cell-selective antiproliferative effect of the extract from Morinda citrifolia fruits

Phytotherapy Research : PTR
Teerakul Arpornsuwan, Tadsanee Punjanon

Abstract

The methanol extract from Morinda citrifolia fruits was tested for cytotoxicity activity on the MTT assay. The appearance of cytotoxic changes after exposure to the extract was in a concentration dependent manner. The median lethal concentrations (LC(50)) of the extract in baby hamster kidney (BHK) cells, African green monkey kidney (Vero) cells and human laryngeal carcinoma (Hep2) cells were found to be 2.5, 3 and 5 mg/mL, respectively. A concentration of 0.1 mg/mL of crude extract exhibited cytotoxic activity against breast cancer (MCF7) and neuroblastoma (LAN5) cell lines at 29% and 36%, respectively. The same concentration of extract showed no toxicity to Vero and very little toxicity to BHK (6%) and Hep2 (13%) cells.

References

Oct 1, 1990·Planta medica·C YounosF Mortier
Aug 7, 1990·Journal of Immunological Methods·M FerrariA M Isetta
Jul 1, 1965·Chemical & Pharmaceutical Bulletin·K NakanishiM Togashi

❮ Previous
Next ❯

Citations

May 24, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·William P ClafshenkelPaula A Witt-Enderby
Dec 4, 2014·Natural Products and Bioprospecting·Dmitri O Levitsky, Valery M Dembitsky
Jan 20, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yougen WuGhee T Tan
May 20, 2017·Phytotherapy Research : PTR·Mylena Andréa Oliveira TorresAna Lucia Abreu-Silva
Nov 13, 2009·Cell Biochemistry and Function·Elif Ilkay TaşkinEngin Ulukaya
Feb 22, 2012·Phytotherapy Research : PTR·Amy C Brown
Dec 17, 2019·Phytotherapy Research : PTR·Bharat Singh, Ram A Sharma
Oct 31, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hanaa H AhmedSoheir E Kotob
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Rakesh Kumar Gupta, Amit Kumar Patel

❮ Previous
Next ❯

Related Concepts