Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma

Oncotarget
Mehdi FarshchianVeli-Matti Kähäri

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal keratinocytes revealed upregulation of the expression of AIM2 mRNA and protein in cSCC cells. Elevated levels of AIM2 mRNA were noted in cSCCs in vivo compared with normal skin. Strong and moderate tumor cell specific expression of AIM2 was detected with immunohistochemistry (IHC) in sporadic human cSCCs in vivo, whereas expression of AIM2 was moderate in cSCC in situ (cSCCIS) and low or absent in actinic keratosis (AK) and normal skin. IHC of cSCCs, cSCCIS and AKs from organ transplant recipients also revealed strong and moderate tumor cell specific expression of AIM2 in cSCCs. Knockdown of AIM2 resulted in reduction in viability of cSCC cells and onset of apoptosis. RNA-seq and pathway analysis after knockdown of AIM2 in cSCC cells revealed downregulation of the biofunction category Cell cycle and upregulation of the biofunction category Cell Death and Survival. Knockdown of AIM2 also resulted in reduction in invasion of cSCC cells and downregulation in production of invasion proteinases MMP...Continue Reading

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Citations

Aug 23, 2018·International Journal of Cancer. Journal International Du Cancer·Claudia Martínez-CardonaJosé Manuel González-Navajas
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May 21, 2021·Immunity, Inflammation and Disease·Huan ZhuHaijing Wu

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Datasets Mentioned

BETA
GSE94270

Methods Mentioned

BETA
xenografts
RNA-seq
PCR
transfection
xenograft

Software Mentioned

Ingenuinity Pathway Analysis

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