Tumor Characteristics and Oncologic Outcome after Radical Prostatectomy in Men 75 Years Old or Older

The Journal of Urology
Philipp MandelDerya Tilki

Abstract

As life expectancy increases, oncologic outcome in elderly patients 75 years old or older is a salient topic requiring further investigation. We analyzed the records of 13,997 patients who underwent radical prostatectomy from 2006 to 2013. Known prognosticators were compared according to age at radical prostatectomy in 13,732 patients younger than 75 years vs 265 patients 75 years old or older. Univariate and multivariate Cox regressions were used to estimate the impact of age on biochemical recurrence-free, metastasis-free, cancer specific and overall survival. Median followup was 47.3 months. Compared to patients younger than 75 years those 75 years old or older had a higher pathological Gleason score (p <0.001) and were more likely to harbor a nonorgan confined tumor (p <0.001), have a positive surgical margin (p = 0.004) and positive lymph nodes (p = 0.028), and receive salvage androgen deprivation therapy (p = 0.002). Five-year biochemical recurrence-free, metastasis-free, cancer specific and overall survival rates were 64.2%, 84.7%, 98.4% and 91.3% in patients 75 years old or older, and 76.9%, 96.2%, 99.0% and 96.2%, respectively, in patients younger than 75 years. On univariate and multivariate analysis age 75 years or g...Continue Reading

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Citations

Apr 26, 2017·Prostate Cancer and Prostatic Diseases·T J DaskivichS J Freedland
Aug 23, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jae Hyun RyuTag Keun Yoo
Dec 14, 2017·Journal of Endourology·Burkhard UbrigAlexander Roosen
Sep 28, 2017·Asian Journal of Andrology·Philipp MandelDerya Tilki
Sep 19, 2017·ANZ Journal of Surgery·Weranja RanasingheShomik Sengupta
May 12, 2017·World Journal of Urology·Annika HerlemannStefan Tritschler
Nov 25, 2021·Journal of Clinical Laboratory Analysis·Jiahao ShanHongbin Shi
Dec 28, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sami-Ramzi Leyh-BannurahJorn H Witt

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