Tumor characteristics and survival analysis of incidental versus suspected gallbladder carcinoma.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Laura M MazerJuan M Sarmiento

Abstract

Over half of all gallbladder carcinoma (GBC) is discovered incidentally after cholecystectomy for benign disease. There are scant data comparing presentation and outcome for patients with incidental versus suspected GBC. The goal of this study is to determine the clinical differences between these two entities. Patients with GBC were identified retrospectively from records at academic healthcare institutions in Temuco, Chile; Atlanta, GA; and Rochester, MN between 1984 and 2008. Overall survival was compared for patients with and without preoperative suspicion using Kaplan-Meier curves and a multivariate Cox proportional hazards model. Of 571 patients, 128 (22.4%) had preoperative suspicion of malignancy, and 443 (77.6 %) were discovered incidentally. Incidental tumors were of lower stage, better differentiated, and with lower rates of metastases. Median survival for incidentally discovered GBC was 32.3 versus 5.8 months for suspected GBC (p<0.0001). In a Cox proportional hazards model controlling for operation extent, T stage, differentiation, and other factors, preoperative suspicion remains a strong risk factor (odds ratio, 2.0; confidence interval, 1.5-2.9; p<0.0001). Tumor characteristics differed significantly between pat...Continue Reading

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Citations

Apr 30, 2014·Cell Biochemistry and Biophysics·Yebo ShaoHoubao Liu
Oct 1, 2015·Journal of Oncology·Rani KanthanSelliah Chandra Kanthan
May 2, 2018·Journal of Surgical Oncology·Chrissy LiuT Clark Gamblin
May 20, 2020·Journal of Clinical Medicine·Jung-Soo PyoKwang Hyun Chung
Feb 6, 2020·Revista do Colégio Brasileiro de Cirurgiões·Welligton Ribeiro FigueiredoMarlon Moreno da Rocha Caminha de Paula
Jun 19, 2021·Cancer Management and Research·Fei LiuFu-Yu Li

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