Tumor characteristics and therapy of elderly patients with breast cancer

Journal of Cancer Research and Clinical Oncology
A-M GrumpeltH Eggemann

Abstract

Elderly breast cancer patients aged ≥75 years are underrepresented in most studies. Therefore, data on cancer characteristics, adjuvant treatment and survival in elderly patients are missing. In this retrospective study, we compared tumor characteristics and adjuvant therapy in 973 women with invasive, non-metastasized breast cancer aged ≥75 years with 3377 younger postmenopausal patients (50-74 years old). Time dynamics of tumor characteristics were investigated, comparing two observation periods between the years 2000-2004 versus 2005-2008. Compared to younger women, older patients were more often treated with mastectomy and less likely to receive adjuvant treatment. Although the overall survival rate increased over the observation period in both age groups, the older study group was characterized by shorter disease-free survival. Additionally, we observed an increase in about 1.65 years in the age at diagnosis as well as an increasing rate of breast-conserving surgery and sentinel lymph node biopsy for the whole study population between 2000 and 2008. Furthermore, we found a reduction in the proportion of estrogen receptor-positive tumors in the younger women and a decrease in G3-tumors in both age groups over the study time...Continue Reading

References

Dec 30, 1999·The New England Journal of Medicine·L F HutchinsK S Albain
Jul 27, 2004·Annals of Surgery·Sebastian F SchoppmannUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Breast Cancer Study GroupAlan S Coates
Sep 19, 2006·American Journal of Surgery·Jennifer R GarreauNathalie Johnson
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shelley M EngerRebecca A Silliman
Feb 6, 2007·The Breast : Official Journal of the European Society of Mastology·I PappoA Halevy
Mar 14, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MustacchiUNKNOWN NORA Study Group
Nov 6, 2009·The Breast Journal·Jim WangGuy Maddern
Mar 24, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mara A SchonbergEllen P McCarthy
Dec 8, 2010·Seminars in Radiation Oncology·Beth M BeadleThomas A Buchholz
Dec 16, 2010·The Oncologist·Hyman B Muss
Mar 17, 2011·The Oncologist·Esther BastiaannetGerrit-Jan Liefers
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon H GiordanoJames S Goodwin
Sep 11, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marije E HamakerJohanneke E A Portielje
May 22, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin S HughesWilliam C Wood
Oct 16, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mariana Chavez-MacGregorSharon H Giordano

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Citations

Apr 1, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jana HornovaTomas Buchler
Apr 4, 2017·International Journal of Radiation Oncology, Biology, Physics·Chris MontenLiv Veldeman
Apr 7, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clark DuMontierWilliam Dale
Jul 3, 2020·Annals of Surgical Oncology·James SunM Catherine Lee
Jun 27, 2019·Current Oncology Reports·Julia FrebaultAmanda L Kong
Jul 11, 2018·Annals of Surgical Oncology·Sarah L BlairLorraine Tafra
Jan 4, 2021·Breast Cancer Research and Treatment·Katelyn SchumacherKelsey E Larson

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