PMID: 6410327Jun 1, 1983Paper

Tumor concentration of platinum in patients with head and neck cancer

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
D E MattoxA J Repta

Abstract

Simultaneous concentrations of total plasma platinum, filterable platinum, intact cisplatin, and total tumor platinum were measured for 24 hours after an intravenous bolus of cisplatin in five patients. Tumor concentrations of drug were greater than could be explained on the basis of circulating plasma platinum at the time of biopsy. Intratumor platinum concentrations derived from this study provide guidance for selection of the appropriate drug concentrations for in vitro chemosensitivity testing of head and neck cancer in humans.

References

Jul 29, 1977·Science·A W Hamburger, S E Salmon
May 1, 1981·Clinical Pharmacology and Therapeutics·K J HimmelsteinL A Sternson
Oct 1, 1980·American Journal of Surgery·D E Mattox, D D Von Hoff

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Citations

Nov 15, 1996·International Journal of Cancer. Journal International Du Cancer·J L LagrangeG Milano
Sep 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·A H Nias
Jan 1, 1985·Archives of Oto-rhino-laryngology·Y OkamotoY Amano
May 28, 1992·International Journal of Cancer. Journal International Du Cancer·T FurukawaM Kitajima
Mar 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R C RichmondC T Coughlin

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