Tumor depth as a predictor of lymph node metastasis of supraglottic and hypopharyngeal cancers

Annals of Surgical Oncology
Masayuki TomifujiAkihiro Shiotani

Abstract

The relationship between the histological parameters of primary lesions and lymph node metastasis in supraglottic and hypopharyngeal cancers has not been elucidated. This analysis is important to evaluate the requirement for additional elective neck dissection when clinically node-negative cancers are treated by transoral surgery. This study included 40 previously untreated patients with supraglottic and hypopharyngeal cancers who underwent transoral en bloc tumor resection in two academic tertiary referral centers. Nodal status was confirmed by neck dissection for cases with findings or suspicion of lymph node metastases or by observation of clinically node-negative cases for more than 1 year. Patients' medical records and pathological features were analyzed retrospectively. The correlation of histological parameters with lymph node metastases, including occult metastases, was evaluated by univariate and multiple logistic regression analyses. Univariate analysis showed that lymph node metastasis was correlated with tumor depth (P = 0.00087) and venous invasion (P = 0.027). Multiple logistic regression analysis showed that it was significantly correlated only with tumor depth (P = 0.007). Tumor depth is the most useful paramete...Continue Reading

References

Aug 26, 1998·The Annals of Otology, Rhinology, and Laryngology·P AmbroschW Steiner
Nov 20, 1998·Archives of Otolaryngology--head & Neck Surgery·H IroW Steiner
Mar 31, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J M Bernstein, M Reddy
May 17, 2002·Cancer·Christian WittekindLeslie H Sobin
Oct 7, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Anthony SparanoRandal Weber
Jan 31, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takako EguchiSatoshi Umemura
Dec 15, 2006·The Annals of Otology, Rhinology, and Laryngology·Giorgio PerettiPiero Nicolai
Dec 20, 2007·The Laryngoscope·Alexios MartinWolfgang Steiner
May 4, 2010·The Annals of Otology, Rhinology, and Laryngology·Akihiro ShiotaniKoichiro Saito

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Citations

Jun 4, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Masayuki TomifujiAkihiro Shiotani
Mar 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jeon Yeob JangHan-Sin Jeong
Jul 27, 2012·Journal of Surgical Oncology·Georgios PsychogiosHeinrich Iro
Dec 19, 2013·Head & Neck·Yong-Hong HuaZhen-Fu Fu
Jan 4, 2017·Clinical and Experimental Otorhinolaryngology·UNKNOWN Korean Society of Thyroid-Head and Neck Surgery Guideline Task ForceKang Dae Lee
Apr 16, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Koji ArakiAkihiro Shiotani
Sep 14, 2012·Head & Neck·Kenji OkamiKoichiro Nishiyama
Oct 24, 2015·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·V DjordjevicZ Petrovic
Mar 23, 2019·Journal of Cancer Research and Clinical Oncology·Silvia Cecilia Pacheco-VelázquezSara Rodríguez-Enríquez
Feb 11, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xiaohui YuanLiang Zhou
Aug 18, 2021·Laryngoscope Investigative Otolaryngology·Keisuke IritaniKen-Ichi Nibu

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