PMID: 7544321Apr 1, 1995Paper

Tumor-derived factor synergizes with IFN-gamma and LPS, IL-2 or TNF-alpha to promote macrophage synthesis of TNF-alpha and TNF receptors for autocrine induction of nitric oxide synthase and enhanced nitric oxide-mediated tumor cytotoxicity

Immunobiology
H JiangR W Leu

Abstract

Evidence has previously been presented for an immunomodulatory role of a soluble activity, designated as tumor-derived recognition factor (TDRF), which was produced constitutively by P815 mastocytoma, L 1210 leukemia and other murine tumor targets. TDRF synergized with IFN-gamma and IL-2 to promote TNF-alpha and mRNA synthesis and release by murine macrophages for increased autocrine induction of nitric oxide (NO)-mediated tumor cytotoxicity. We have now further assessed the modulatory role of TDRF on TNF-alpha, TNF receptors (TNF-R) and NOS mRNA synthesis. Macrophages activated by INF-gamma priming and triggering by rTNF-alpha bacterial lipopolysaccharide (LPS) of IL-2 evoked greater NO generation in the presence than in the absence of L1210 targets. TDRF-containing culture fluid from L1210 targets was subsequently confirmed to synergize with IFN-gamma and rTNF-alpha, LPS or IL-2 triggering agents to promote increased TNF-alpha mRNA for autocrine induction of NOS mRNA synthesis with resultant augmentation of NO generation. IFN-gamma selectively upregulated TNF-R1 mRNA expression, whereas either IL-2 or LPS upregulated only TNF-R2 mRNA expression. TDRF combined with IFN-gamma to further upregulate TNF-R1 mRNA and with either IL...Continue Reading

References

Oct 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·L A TartagliaD V Goeddel
Apr 1, 1990·The Journal of Experimental Medicine·S Srimal, C Nathan
Jan 22, 1986·Journal of Immunological Methods·J A RummageR W Leu

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Citations

Nov 9, 2006·Journal of Biomedical Science·Shyi-Shiaw JiauMao-Hsiung Yen
Oct 24, 2003·Breast Cancer Research and Treatment·Christoph C ZielinskiChristoph Wiltschke
Aug 28, 2013·Virology Journal·Kátia Paulino Ribeiro de SouzaMarco Antônio Campos
Dec 22, 2006·Biochemical Pharmacology·Pao-Yun ChengMao-Hsiung Yen
Oct 27, 2005·Leukemia Research·Cinthya Guimaraes-SternbergHermona Soreq
Jan 23, 1997·Biochemical and Biophysical Research Communications·M TonettiA De Flora
May 12, 2006·American Journal of Physiology. Cell Physiology·Fabrice PorcherayGabriel Gras
Jun 24, 2008·Immunopharmacology and Immunotoxicology·Alok Kumar SinghSukh Mahendra Singh
Dec 14, 2004·Journal of Biomedical Science·Chien-Chuan WangMao-Hsiung Yen

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