Tumor-derived TGFbeta-1 induces dendritic cell apoptosis in the sentinel lymph node

The Journal of Immunology : Official Journal of the American Association of Immunologists
Manabu ItoJun-ichi Ogawa

Abstract

Lymphatic flux from a primary tumor initially flows into a tumor-draining lymph node (LN), the so-called sentinel LN (SLN). Carried by the lymph fluid are a variety of mediators produced by the tumor that can influence immune responses within the SLN, making it a good model with which to investigate tumor-related immunology. For instance, dendritic cell (DC) numbers are reduced in SLNs from melanoma and breast cancer patients. In the present study, we investigated the mechanism by which DC numbers were reduced within SLNs from patients with non-small cell lung cancer. We found that the incidence of apoptosis among DCs was higher in SLNs than in non-SLNs, as were levels of TGFbeta-1. In contrast, levels of TGFbeta-1 mRNA did not differ between SLNs and non-SLNs, but were 30 times higher in tumors than in either LN type. In vitro, incubation for 2 days with TGFbeta-1 induced apoptosis among both cultured DCs and DCs acutely isolated from normal thoracic LNs, effects that were blocked by the TGFbeta-1 inhibitor DAN/Fc chimera. Taken together, these results suggest that tumor-derived TGFbeta-1 induces immunosuppression within SLNs before the movement of tumor cells into the SLNs, thereby facilitating metastasis within those nodes.

References

Sep 1, 1995·Annals of Surgery·A E GiulianoD L Krasne
Jan 1, 1997·Breast Cancer Research and Treatment·K D Amoils, W R Bezwoda
Jun 25, 1998·International Journal of Cancer. Journal International Du Cancer·C Asselin-PaturelF Mami-Chouaib
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M KiertscherM D Roth
Jun 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A J CochranD R Wen
Aug 22, 2001·The Journal of Experimental Medicine·W ChenS M Wahl
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J LiptayWilliam Watkin
Aug 10, 2002·Seminars in Oncology·Jeannie ShenMichael Bouvet
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Taku NakagawaJun-ichi Ogawa
Oct 2, 2003·Brain Research. Developmental Brain Research·Anthony S Kim, Samuel J Pleasure
Jun 15, 2004·Journal of the American College of Surgeons·Rene Lafrenière
Jun 26, 2004·Breast Cancer Research : BCR·Nancy J PoindexterElizabeth A Grimm
Sep 8, 2004·Experimental and Molecular Pathology·R NunezL Filgueira
Nov 9, 2004·Advances in Cancer Research·Li Yang, David P Carbone
Dec 15, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hiroaki YanagimotoYasuo Kamiyama
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lyudmila A LyakhAnita B Roberts
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heinfried H RadekeBurkhard Kleuser

❮ Previous
Next ❯

Citations

May 3, 2007·Cancer Immunology, Immunotherapy : CII·Fu-Li WangHe Wang
Dec 2, 2008·Pigment Cell & Melanoma Research·Sanaa El MarsafyAlain Mauviel
Jul 20, 2010·Immunological Reviews·Min Chen, Jin Wang
Jun 8, 2012·Cancer Immunology, Immunotherapy : CII·Miriam AlbDavid Schrama
Dec 21, 2012·Expert Review of Anticancer Therapy·Leisha A Emens
Oct 23, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jonathan P Sleeman
Mar 18, 2016·Cancer Immunology, Immunotherapy : CII·Jinbao ZongMichael R Shurin
Jun 15, 2019·International Journal of Molecular Sciences·Yang HaoPeter Ten Dijke
Sep 16, 2006·Immunological Reviews·Sharon M WahlNiki Moutsopoulos
Nov 15, 2006·Journal of Biomedical Science·Chih-Ping MaoT-C Wu
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria L BelladonnaPaolo Puccetti
Jul 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rahul Kushwah, Jim Hu
Oct 30, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Aziz Alami ChentoufiLbachir BenMohamed
Sep 17, 2014·Expert Review of Clinical Immunology·Marco TucciFranco Silvestris
Jun 12, 2013·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Galina V ShurinMichael R Shurin
Apr 18, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rumeysa CiftciSezai Vatansever
Jul 20, 2013·BMC Immunology·Jon G QuatromoniSunil Singhal
Aug 30, 2016·CA: a Cancer Journal for Clinicians·Fernanda G HerreraGeorge Coukos
Nov 17, 2007·Blood·Ren-In YouShie-Liang Hsieh
Oct 16, 2009·International Journal of Cancer. Journal International Du Cancer·Shun TakakuJay A Berzofsky
May 28, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yoshihiro MinamiyaJun-ichi Ogawa
Oct 7, 2006·American Journal of Respiratory Cell and Molecular Biology·Alexander FaithCatherine Hawrylowicz
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rahul KushwahJim Hu
Jul 10, 2010·Nature Reviews. Immunology·Richard A FlavellPaula Licona-Limón
Jan 3, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Leonardo Araújo MelloJean Nunes Dos Santos
May 27, 2016·American Journal of Veterinary Research·Qian ZhangYan Cui
Aug 7, 2008·PloS One·Claudia E RübeChristian Rübe
May 1, 2007·Expert Review of Clinical Immunology·Silvia Della BellaMaria Luisa Villa
Jan 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siping MinRongcun Yang
Jan 12, 2012·Journal of Experimental & Clinical Cancer Research : CR·Kazuhiro ImaiJun-Ichi Ogawa
Nov 16, 2011·Melanoma Research·Travis E GrotzSvetomir N Markovic
Jul 11, 2012·Clinical & Developmental Immunology·Ning-Bo HaoShi-Ming Yang
Aug 31, 2018·Acta Biochimica Et Biophysica Sinica·Shuchen Gu, Xin-Hua Feng
Mar 31, 2011·Journal of Cellular Physiology·Antonella NaldiniFabio Carraro
Dec 4, 2012·Viruses·Sharon de T MartinsJuliano Bordignon
Mar 13, 2018·Frontiers in Oncology·Dennis JonesTimothy P Padera
May 27, 2020·Medical Microbiology and Immunology·Charlotte M de WindeSophie E Acton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.