Tumor-derived VEGF-C, but not VEGF-D, promotes sentinel lymph node lymphangiogenesis prior to metastasis in breast cancer patients.

Medical Oncology
Ying-Chun ZhaoShui Wang

Abstract

Breast cancer usually initially metastases to the sentinel lymph nodes (SLNs). Recent studies have demonstrated that tumor cells induce SLN lymphangiogenesis before metastasis in several malignancies. In addition, tumor-derived VEGF-C or VEGF-D may induce lymphangiogenesis and promote lymph node metastasis. To explore the mechanisms of lymph node metastasis in breast cancer, we investigated whether primary tumors induce SLN lymphangiogenesis before metastasis and determined the function of tumor-derived VEGF-C and VEGF-D in SLN lymphangiogenesis. Expression of VEGF-C and VEGF-D was examined using immunohistochemistry in 63 primary breast tumors. No significant relationships between VEGF-C and VEGF-D (P=0.420), and VEGF-C or VEGF-D expression and clinical parameters (age, tumor size, grade, hormonal receptor status, her-2 status) were observed (P>0.05). Expression of the lymphatic-specific markers VEGFR-3, Prox-1 and LYVE-1 was measured using quantitative real-time RT-PCR in uninvolved SLNs from 63 patients and compared to control lymph nodes from patients with benign breast disease. Expression of Prox-1 and LYVE-1 mRNA was significantly higher in uninvolved SLNs from breast cancer patients than that in control lymph nodes (P<0....Continue Reading

References

Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·A KaipainenK Alitalo
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G AchenS A Stacker
Mar 30, 2001·The Journal of Biological Chemistry·R PrevoD G Jackson
Apr 21, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y YonemuraT Sasaki
Jul 5, 2001·Breast Cancer Research and Treatment·J KinoshitaK Sugimachi
Oct 12, 2001·Microscopy Research and Technique·M A Swartz, M Skobe
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Young-Kwon HongGuillermo Oliver
Apr 15, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yasushi NakamuraKennichi Kakudo
Jul 31, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F J HoarP S Stonelake
Feb 27, 2004·Biochimica Et Biophysica Acta·Yulong HeKari Alitalo
Jan 26, 2005·The Journal of Clinical Investigation·Peter BalukDonald M McDonald
Apr 6, 2005·The Journal of Experimental Medicine·Satoshi HirakawaMichael Detmar
May 4, 2005·Breast Cancer Research and Treatment·Yasushi NakamuraKennichi Kakudo
Oct 26, 2005·International Journal of Clinical Oncology·Yutaka YonemuraMasahiro Miura
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan JüttnerMichael Höcker
Dec 16, 2005·Nature·Kari AlitaloTatiana V Petrova
Nov 30, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E MylonaL Nakopoulou
Jan 27, 2007·The American Journal of Pathology·Maria I HarrellAlanna Ruddell
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gert G Van den EyndenEric A Van Marck

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Citations

Jul 25, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B YangL Li
Nov 14, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mao WatanabeKosei Hirakawa
Aug 6, 2013·Oncogene·R H FarnsworthS A Stacker
Apr 30, 2016·Cellular Oncology (Dordrecht)·Roman Paduch
May 18, 2016·Breast Cancer Research and Treatment·Wenbin ZhouShui Wang
Aug 17, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jingwen WangJianwu Tang
Apr 26, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Man ChenXiao-chun Fei
Oct 16, 2015·Ophthalmic Plastic and Reconstructive Surgery·César A BriceñoHakan Demirci
Mar 22, 2014·Molecular and Clinical Oncology·En-Qi QiaoJi-Hai Tang
Dec 16, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Caiqi MaXia Yang
Apr 19, 2015·Experimental Biology and Medicine·Chu-An Wang, Shaw-Jenq Tsai
May 13, 2018·Journal of Cellular and Molecular Medicine·Jan W RoberingAnja M Boos
Apr 29, 2020·Journal of Extracellular Vesicles·Chu-An WangShaw-Jenq Tsai
Jul 10, 2021·Cellular and Molecular Life Sciences : CMLS·Lionel GillotAgnès Noël

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