Tumor dormancy as an alternative step in the development of chemoresistance and metastasis - clinical implications

Cellular Oncology (Dordrecht)
Federico RossariEnrico Orciuolo

Abstract

The ability of a tumor to become dormant in response to suboptimal conditions has recently been recognized as a key step in tumor progression. Tumor dormancy has been found to be implicated in several tumor types as the culprit of therapy resistance and metastasis development, the deadliest features of a cancer. Several lines of evidence indicate that the development of these traits may rely on the de-differentiation of committed tumor cells that regain stem-like properties during a dormant state. Presently, dormancy is classified into cell- and population-level, according to the preponderance of cellular mechanisms that keep tumor cells quiescent or to a balance between overall cell division and death, respectively. Cellular dormancy is characterized by autophagy, stress-tolerance signaling, microenvironmental cues and, of prime relevance, epigenetic modifications. It has been found that the epigenome alters during cellular quiescence, thus representing the driving force for short-term cancer progression. Population-level dormancy is characterized by processes that counteract proliferation, such as inappropriate blood supply and intense immune responses. The latter two mechanisms are not mutually exclusive and may affect tumor...Continue Reading

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Citations

Mar 3, 2020·The Tohoku Journal of Experimental Medicine·Rosa María Márquez-GonzálezMónica Alejandra Rosales-Reynoso
Dec 9, 2020·Stem Cells and Development·Caroline HochheuserIlse Timmerman
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Nov 11, 2021·Biology of the Cell·Mangala HegdeManjunath B Joshi

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Methods Mentioned

BETA
histone acetylation
GTPase
acetylation
xenograft
biopsies

Clinical Trials Mentioned

NCT00990054
NCT01120457
NCT00943943
NCT00906945
NCT01027923
NCT01160354

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