PMID: 6979522Apr 15, 1982Paper

Tumor enhancing T lymphocytes in mice: further studies on characteristics and mechanism of activity

International Journal of Cancer. Journal International Du Cancer
M Small

Abstract

In order to test the possibility that tumor-enhancing T lymphocytes can suppress other lymphoid cells, such as those with anti-tumor activity, their effect was tested in an allogeneic response of cell-mediated lysis. Normal thymocytes and spleen cells from mice with advanced tumors, two populations which enhance the growth of solid tumors, both suppressed the generation of CML. Since these results suggest that the mechanism of enhancement by T cells may resemble suppression in other immune responses, we looked for Fc receptors on the sensitized cells involved in tumor enhancement. Cells expressing Fc receptors appeared to be necessary for enhancement of tumor growth to occur.

References

Jan 1, 1979·Journal of Immunological Methods·M ShimizuT Ohara
Jan 1, 1977·Contemporary Topics in Molecular Immunology·R W Baldwin, R A Robins
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I HellströmI D Bernstein
Dec 15, 1976·International Journal of Cancer. Journal International Du Cancer·A GabizonN Trainin
Jun 15, 1975·International Journal of Cancer. Journal International Du Cancer·M Small, N Trainin
Nov 1, 1974·European Journal of Immunology·A J TrevesI R Cohen
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H O SjögrenK E Hellström

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Citations

Aug 1, 1987·Immunology and Cell Biology·D S Nelson, M Nelson
Mar 28, 2008·Immunological Reviews·Richmond T Prehn, Liisa M Prehn

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