Tumor-grade hyperprolactinemia induced by multiple medications in the setting of renal failure.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
K Ziambaras, S Dagogo-Jack

Abstract

To describe a patient with galactorrhea and severe hyperprolactinemia in whom workup revealed a nontumoral mechanism. We present the medical history of a woman with long-standing diabetes in whom bilateral galactorrhea and hyperprolactinemia developed. In addition, the details of her clinical course and management are reviewed. A 33-year-old woman with diabetes, end-stage renal disease, and gastroparesis was admitted to the hospital because of intractable nausea and vomiting. Several months before admission, she had been noted to have galactorrhea and irregular menses. Routine medications included captopril, verapamil, furosemide, prochlorperazine, metoclopramide, cisapride, and Ortho-Novum. Laboratory evaluation showed normal thyroid function, increased serum prolactin levels (up to 1,197 ng/mL), and normal findings on magnetic resonance imaging of the pituitary. Electrophoresis of the patient's serum on a protein A Sepharose column showed no evidence of macro-prolactinemia. Orally administered medications were discontinued, and the patient was given total parenteral nutrition. These measures resulted in a decrease of 300 ng/mL in serum prolactin levels in 4 days. The prolactin levels eventually normalized after withdrawal of ...Continue Reading

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Citations

May 25, 2007·Journal of Women's Health·Kathryn GrantUNKNOWN Florida Behavioral Health Research Consortium
May 25, 2006·Obstetrical & Gynecological Survey·Brain M Casey
Dec 5, 2009·CNS Drugs·Chaya G BhuvaneswarJonathan E Alpert

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