Tumor growth control using red blood cells as the antigen delivery system and poly(I:C)

Journal of Immunotherapy
Alice BanzYann Godfrin

Abstract

The goal of most current vaccines in tumor immunology is to induce an efficient immune response against the tumor cells. The use of red blood cells (RBCs) for the delivery of tumor-associated antigen to antigen-presenting cells is an innovative approach for cancer immunotherapy. The induction of antigen-specific immune responses after administration of antigen-loaded RBCs has been demonstrated previously in mice. In this paper, we show the utility of this delivery system for cancer immunotherapy in 2 tumor mouse models, using the E.G7-OVA and the B16F10 tumor cells. The non-self-antigen, ovalbumin, loaded in RBCs and the self-tumor antigen, tyrosinase-related protein 2, loaded in RBCs were tested in the E.G7-OVA and the B16F10 tumor models, respectively. We showed that not only protein but also peptide could be efficiently entrapped in RBCs by a controlled lysis/resealing process. In both antigen models, the administration of a small quantity of antigen loaded in RBCs combined with polyinosinic-polycytidylic acid induced an antigen-specific T-cell response and the control of tumor growth in mice, whereas the injection of the same quantity of free antigen did not. The intensity of the T-cell response was dependent on the concent...Continue Reading

Citations

Oct 11, 2012·Immunotherapy·Yann GodfrinMagali Cremel
May 18, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Yu-Wen WuThierry Burnouf
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shishir Kumar GuptaA P Sahoo
Jul 4, 2017·Journal of Drug Targeting·Munazza Tamkeen FatimaMehboob Hoque
Mar 22, 2020·Pharmaceutics·Larisa KolevaElena Sinauridze
Dec 18, 2013·Advanced Healthcare Materials·Kyle K L PhuaSmita K Nair
Mar 17, 2021·European Journal of Pharmacology·Nur Najihah Izzati Mat RaniMohd Cairul Iqbal Mohd Amin
Apr 4, 2020·Cell·Zongmin ZhaoSamir Mitragotri
Aug 9, 2021·Advanced Drug Delivery Reviews·Guangna LiuGuangjun Nie
Mar 7, 2019·ACS Nano·Eliran Moshe ReuvenVered Padler-Karavani
Dec 12, 2017·Bioconjugate Chemistry·Chao WangZhen Gu

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