PMID: 51839Oct 1, 1975Paper

Tumor growth inhibition by ammonium chloride-induced acidosis

International Journal of Clinical Pharmacology and Biopharmacy
L J Anghileri

Abstract

Ammonium chloride-induced metabolic acidosis decreases the growth of various experimental tumors. Spleen exhibits the same effects. There is a sex factor which seems to affect the growth of both tumor and spleen. The observed tumor inhibition appears to be related to a systemic impairment of the anabolic mechanisms. The decrease in tumor calcium suggests that this element may play a role in the tissue growth. The possible implication of cell membrane changes and of a block in glycolysis in the acidosis effects are discussed.

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