Tumor growth inhibitory and natural suppressor activities of murine bone marrow cells: a comparative study

Cellular Immunology
Victor I SeledtsovVladimir A Kozlov

Abstract

The murine bone marrow (BM) cells having a certain phenotypic similarity to null natural suppressor (NS) cells have been previously established to be able to inhibit in vitro leukemic cell growth in a genetically unrestricted manner. In this study we found that the treatment of normal (C57BL/6 x DBA)F1 BM cells with a lysosomotropic agent, L-leucine methyl ester (LME), largely abrogated their ability to reduce both P815 mastocytoma and L1210 lymphoma cell proliferation, as well as their NS activity tested for suppression of mitogen (Con A or LPS)-driven spleen cell proliferation. However, after being depleted of the cells binding wheat germ agglutinin (WGA), the BM cells maintained tumor growth-inhibitory activity, while demonstrating no significant NS activity. Moreover, in contrast to T-cell blastogenesis-inhibitory NS activity of BM cells, that was greatly reduced by the addition into the culture of either neutralizing anti-interferon (IFN)-gamma antibody (Ab) or NG-monomethyl-L-arginine, a competitive inhibitor of NO synthase, natural antitumor cytostatic activity of BM cells was not found to be dependent on the presence in medium of IFN-gamma and to be associated with NO production. When incubated at suboptimal numbers wit...Continue Reading

Citations

Aug 20, 2005·Leukemia & Lymphoma·V I SeledtsovV A Kozlov
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Nicolas LarmonierFrançois Martin
Sep 8, 2000·Bulletin of Experimental Biology and Medicine·N V Bel'skayaV I Agafonov
Jul 20, 2005·Bulletin of Experimental Biology and Medicine·Yu P Bel'skiiV I Agafonov
Sep 29, 2020·Expert Opinion on Biological Therapy·Victor I Seledtsov, Alexei von Delwig
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B PeláezJ L Subiza

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