Tumor histology affects the accuracy of clinical evaluative staging in primary lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Yasunobu FunakoshiTomohiro Kawamura

Abstract

Pathological examination of lung cancer often reveals a more advanced stage than clinical stage. The objective of this study was to evaluate whether the association between clinical and pathologic stages depends on tumor histology. This retrospective study enrolled patients who had undergone major lung resections and systemic lymph node dissections (1990-2004). In total, 483 patients had adenocarcinoma and 225 had squamous cell carcinoma. Clinical and pathologic N-status were significantly different in patients with adenocarcinoma (p<0.0001) but not in those with squamous cell carcinoma. Patients with adenocarcinoma were more likely to be upstaged from clinical N0 disease to pathologic N2 disease than those with squamous cell carcinoma (p = 0.04). Of those patients with adenocarcinoma, surgical procedure, clinical N-status, metastatic pathologic N2 stations and curability were significant prognostic factors. It is of interest, however, that a similar statistically significant difference could not be shown in patients with squamous cell carcinoma. Furthermore, multivariate analysis demonstrated that clinically detectable N2 disease and multiple pathologic N2 stations significantly affected the poorer prognosis in adenocarcinoma....Continue Reading

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Citations

Mar 24, 2012·Revue des maladies respiratoires·F Le Pimpec BarthesM Riquet
Feb 1, 2013·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Halide Nur UrerSeyyit Ibrahim Dincer
Jan 10, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Marlies E HeuversRob J van Klaveren

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