PMID: 12758235May 22, 2003Paper

Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Johan BussinkA J van der Kogel

Abstract

Tumor oxygenation is recognized as an important determinant of the outcome of radiotherapy and possibly also of other treatment modalities in a number of tumor types and in particular in squamous cell carcinomas. The hypoxic status of various solid tumors has been related to a poor prognosis due to tumor progression towards a more malignant phenotype, with increased metastatic potential, and an increased resistance to treatment. It has been demonstrated in head and neck cancer that hypoxic radioresistance can be successfully counteracted by hypoxia modifying approaches. The microregional distribution and the level of tumor hypoxia depend on oxygen consumption and temporal and spatial variations in blood supply. It is unclear if severely hypoxic cells can resume clonogenicity when O(2) and nutrients become available again as a result of (treatment related) changes in the tumor microenvironment. Non-terminally differentiated hypoxic cells that are capable of proliferation are important for outcome because of their resistance to radiotherapy and possibly other cytotoxic treatments. Various exogenous and endogenous markers for hypoxia are currently available and can be studied in relation to each other, the tumor architecture and t...Continue Reading

References

Nov 1, 1978·The British Journal of Radiology·E R WatsonI Sutherland
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Aug 16, 1989·Journal of the National Cancer Institute·R E WilsonR M Sutherland
May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·R A GatenbyG J Broder
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·R F Kallman, M J Dorie
Sep 1, 1981·The Journal of Cell Biology·F M Watt, H Green
Jul 1, 1995·The Journal of Urology·T M JaegerP R Carroll
Jul 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P L Olive
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J M ClineJ A Raleigh
Mar 1, 1994·International Journal of Cancer. Journal International Du Cancer·P MellanenP Härkönen
Sep 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G D WilsonM I Saunders
Oct 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E L LevineR D Hunter
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·A RojasH Johns
Jul 1, 1996·International Journal of Radiation Oncology, Biology, Physics·M NordsmarkJ Overgaard
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·J R GnarraW M Linehan
Oct 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M NordsmarkJ Overgaard
Feb 13, 1997·Oncogene·Z Kelman
Nov 1, 1996·Pathology, Research and Practice·N JenssenM Bryne
Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·A S KennedyM A Varia
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D M BrizelM W Dewhirst
Aug 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B M Fenton
May 8, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Daşu, J Denekamp
May 12, 1998·Molecular Medicine Today·J M Gleadle, P J Ratcliffe
Jun 20, 1998·Seminars in Radiation Oncology·M W Dewhirst
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·S V IvanovM I Lerman
Oct 20, 1998·The Laryngoscope·A KropveldG J Hordijk
Dec 9, 1998·International Journal of Radiation Oncology, Biology, Physics·R E Durand, E Sham
May 4, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A C BeggG D Wilson
May 4, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R W TsangC S Wong
May 4, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R W TsangM Pintilie
May 29, 1999·International Journal of Radiation Oncology, Biology, Physics·M T SheridanC M West
Jun 15, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J BussinkA J van der Kogel
Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·P StadlerM Molls

❮ Previous
Next ❯

Citations

Oct 18, 2006·European Radiology·Anwar R PadhaniMarkus Alber
May 18, 2012·Cell and Tissue Research·A C MamedeM F Botelho
Apr 17, 2008·Cancer Metastasis Reviews·Aaron P BrownKevin A Camphausen
Apr 19, 2013·Cancer Metastasis Reviews·Jean-Emmanuel BibaultEric Deutsch
Apr 20, 2005·Journal of Mammary Gland Biology and Neoplasia·Michael F InsanaKaren K Lindfors
Apr 12, 2008·Journal of Neuro-oncology·Joachim B SchnierFredric A Gorin
Jul 3, 2008·Journal of Neuro-oncology·S KumarJ H Kim
Sep 15, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Xilin SunXiaoyuan Chen
Feb 22, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ning ZhouHu Guoqing
Mar 10, 2004·Bioorganic & Medicinal Chemistry Letters·Maria V PapadopoulouWilliam D Bloomer
Apr 10, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Bradly G WoutersCostas Koumenis
Mar 19, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael BaumannJan Willem Leer
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Jan 26, 2011·Nature Reviews. Clinical Oncology·Johan BussinkWim J G Oyen
Nov 15, 2012·Nature Reviews. Clinical Oncology·Michael R HorsmanJens Overgaard
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Sep 27, 2007·Journal of the National Cancer Institute·Olivier TrédanIan F Tannock
Jan 20, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Sep 29, 2004·Journal of Clinical Pathology·A E Greijer, E van der Wall
Aug 1, 2009·Journal of Oncology·Sameer K NathAjay P Sandhu
Apr 12, 2011·Radiation Oncology·Vasileios AskoxylakisPeter E Huber
Jan 25, 2013·World Journal of Gastroenterology : WJG·Abobakr K ShadadLaurence J Egan
Sep 1, 2007·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Yoon Seok ChoiJun Suk Kim
Oct 4, 2012·Future Oncology·Neesha Dhani, Michael Milosevic
Dec 18, 2013·Antioxidants & Redox Signaling·Chen-Ting LeeMark W Dewhirst
Apr 19, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Esther G C TroostJohan Bussink
May 25, 2012·The British Journal of Radiology·I Mendichovszky, A Jackson
Feb 15, 2011·Research in Veterinary Science·G MeesC Van de Wiele
Feb 6, 2015·Expert Opinion on Therapeutic Targets·Dominik HornChristian Freudlsperger
Sep 8, 2015·Progress in Retinal and Eye Research·Bruce A BerkowitzRobin Roberts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Marianne NordsmarkJames A Raleigh
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Marianne NordsmarkJens Overgaard
International Journal of Radiation Oncology, Biology, Physics
Hilde L K JanssenAdrian C Begg
© 2022 Meta ULC. All rights reserved