Tumor Hypoxia Response After Targeted Therapy in EGFR-Mutant Non-Small Cell Lung Cancer: Proof of Concept for FMISO-PET

Technology in Cancer Research & Treatment
Nils D ArvoldUmar Mahmood

Abstract

Hypoxia is associated with resistance to radiotherapy and chemotherapy. Functional imaging of hypoxia in non-small cell lung cancer (NSCLC) could allow early assessment of tumor response and guide subsequent therapies. Epidermal growth factor receptor (EGFR) inhibition with erlotinib reduces hypoxia in vivo. [18F]-Fluoromisonidazole (FMISO) is a radiolabeled tracer that selectively accumulates in hypoxic cells. We sought to determine whether FMISO positron emission tomography (FMISO-PET) could detect changes in hypoxia in vivo in response to EGFR-targeted therapy. In a preclinical investigation, nude mice with human EGFR-mutant lung adenocarcinoma xenografts underwent FMISO-PET scans before and 5 days after erlotinib or empty vehicle initiation. Descriptive statistics and analysis of variance (ANOVA) tests were used to analyze changes in standardized uptake value (SUV), with pooled analyses for the mice in each group (baseline, postvehicle, and posterlotinib). In a small correlative pilot human study, patients with EGFR-mutant metastatic NSCLC underwent FMISO-PET scans before and 10 to 12 days after erlotinib initiation. Changes in SUV were compared to standard chest computed tomography (CT) scans performed 6 weeks after erloti...Continue Reading

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References

Jan 1, 1990·Advances in Experimental Medicine and Biology·P VaupelP Okunieff
Mar 22, 2003·Experimental Cell Research·Robert N JorissenAntony W Burgess
May 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masahiro FukuokaJosé Baselga
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Oct 14, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Bernd GagelMichael J Eble
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Dec 19, 2007·International Journal of Radiation Oncology, Biology, Physics·Sadek A NehmehJohn L Humm
Mar 4, 2008·International Journal of Radiation Oncology, Biology, Physics·Zhixiong LinC Clifton Ling
May 7, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistThomas J Lynch
May 17, 2008·Cancer Metastasis Reviews·Quynh-Thu Le, Don Courter
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas ZanderJürgen Wolf
Jan 17, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shozo OkamotoNagara Tamaki
Dec 18, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Fenglei WuNan Hu

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Citations

Aug 11, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Anna G SoraceThomas E Yankeelov
Oct 12, 2016·AJR. American Journal of Roentgenology·Sara SheikhbahaeiRathan M Subramaniam
Sep 20, 2017·Journal of the National Cancer Institute·Ahmed SalemCorinne Faivre-Finn
Dec 20, 2019·Journal of Thoracic Imaging·Darragh HalpennyMichelle S Ginsberg
Jul 17, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zhaoguo HanXilin Sun
Dec 24, 2019·Current Radiopharmaceuticals·Silvi TeloStefano Fanti

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