Tumor imaging with a macromolecular paramagnetic contrast agent: gadopentetate dimeglumine-polylysine

Academic Radiology
L R OpsahlDavid R Vera

Abstract

We evaluated magnetic resonance (MR) contrast enhancement of tumor tissue following injection of the macromolecular conjugate, gadopentetate dimeglumine-polylysine. T1-weighted MR imaging scans were performed on female Fisher-344 rats with subcutaneously implanted mammary adenocarcinoma tumors. Following the baseline scan, gadopentetate dimeglumine-polylysine or gadopentetate dimeglumine was injected at a dose of 0.1 mmol gadolinium per kilogram. Gadopentetate dimeglumine-polylysine injection resulted in a maximum enhancement of tumor contrast of 310 +/- 60% (n = 7). Tumor tissue remained enhanced and well defined for several days after gadopentetate dimeglumine-polylysine injection. Gadopentetate dimeglumine injection at the same dose resulted in a 70 +/- 25% (n = 4) maximal tumor enhancement and a corresponding 25 +/- 4% muscle enhancement. Gadopentetate dimeglumine-polylysine provides higher, more sustained tumor contrast than does gadopentetate dimeglumine for the same dosage of gadolinium.

Citations

Oct 12, 2007·Bioconjugate Chemistry·Lindsay S KarfeldAnnelise E Barron
Jun 26, 2008·Journal of the American Chemical Society·Jenny J YangZhi-Ren Liu
Apr 13, 2004·Investigative Radiology·Egidijus Uzgiris
Aug 13, 2015·Contrast Media & Molecular Imaging·Tatiana AbakumovaVladimir Chekhonin
Mar 19, 2013·Journal of Healthcare Engineering·Weiren ChengYe Liu
Dec 15, 2004·Academic Radiology·Claude B SirlinRobert F Mattrey
May 3, 2014·Advanced Drug Delivery Reviews·Kevin M BennettIchio Aoki
Apr 8, 2017·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Teruyuki KondoYasuhiro Aoyama
Feb 16, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Carlo DiaferiaAntonella Accardo

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