Tumor-induced CD11b+Gr-1+ myeloid cells suppress T cell sensitization in tumor-draining lymph nodes

The Journal of Immunology : Official Journal of the American Association of Immunologists
Satoshi WatanabeS Shu

Abstract

Suppression of tumor-specific T cell sensitization is a predominant mechanism of tumor escape. To identify tumor-induced suppressor cells, we transferred spleen cells from mice bearing progressive MCA205 sarcoma into sublethally irradiated mice. These mice were then inoculated subdermally with tumor cells to stimulate T cell response in the tumor-draining lymph-node (TDLN). Tumor progression induced splenomegaly with a dramatic increase (22.1%) in CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSC) compared with 2.6% of that in normal mice. Analyses of therapeutic effects by the adoptive immunotherapy revealed that the transfer of spleen cells from tumor-bearing mice severely inhibited the generation of tumor-immune T cells in the TDLN. We further identified MDSC to be the dominant suppressor cells. However, cells of identical phenotype from normal spleens lacked the suppressive effects. The suppression was independent of CD4(+)CD25(+) regulatory T cells. Intracellular IFN-gamma staining revealed that the transfer of MDSC resulted in a decrease in numbers of tumor-specific CD4(+) and CD8(+) T cells. Transfer of MDSC from MCA207 tumor-bearing mice also suppressed the MCA205 immune response indicating a lack of immunologic sp...Continue Reading

References

Apr 1, 1966·Journal of the National Cancer Institute·H Wexler
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S A KusmartsevS H Chen
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D I GabrilovichW M Kast
Jul 26, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Takashi HayashiSuyu Shu
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li-Xin WangGregory E Plautz
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vincenzo BrontePaola Zanovello
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuanqing LiuAnja B Geldhof
Jul 17, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jørgen KjaergaardSuyu Shu
Nov 1, 2003·Cancer Immunology, Immunotherapy : CII·Paolo SerafiniVincenzo Bronte
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevDmitry I Gabrilovich
Feb 12, 2004·Cancer Research·Qingsheng LiShu-Hsia Chen
Sep 3, 2004·Nature Reviews. Immunology·Michal Baniyash
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul A AntonyNicholas P Restifo
Jul 28, 2005·Cancer Immunology, Immunotherapy : CII·Sergei Kusmartsev, Dmitry I Gabrilovich
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eiji SuzukiSteven M Albelda
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevDmitry I Gabrilovich
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie K BuntSuzanne Ostrand-Rosenberg
Jan 21, 2006·Cancer Research·Claire E Lewis, Jeffrey W Pollard
Mar 25, 2006·Nature Reviews. Immunology·Weiping Zou
Sep 16, 2006·Immunological Reviews·David H Munn, Andrew L Mellor
Oct 4, 2006·The Journal of Clinical Investigation·Giovanna GallinaVincenzo Bronte
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristian M HargadonVictor H Engelhard
Dec 1, 2006·Annual Review of Immunology·Gabriel A RabinovichEduardo M Sotomayor
Jul 3, 2007·Nature Medicine·Srinivas NagarajDmitry I Gabrilovich
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratima SinhaSuzanne Ostrand-Rosenberg
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James E Talmadge
Oct 3, 2007·Cancer Research·Carolyn E ClarkRobert H Vonderheide
Mar 28, 2008·Immunological Reviews·Ilaria MarigoVincenzo Bronte

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Citations

Feb 25, 2009·Cancer Immunology, Immunotherapy : CII·Joseph Lustgarten
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erica M HansonSuzanne Ostrand-Rosenberg
Feb 3, 2011·European Journal of Immunology·Jessica M HaverkampTimothy L Ratliff
Sep 8, 2011·International Journal of Cancer. Journal International Du Cancer·Jung-Mi LeeChang-Yuil Kang
May 3, 2013·Cancer Metastasis Reviews·Jaclyn SceneayAndreas Möller
Jun 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wataru FujiiYutaka Kawahito
Jul 3, 2013·Inflammatory Bowel Diseases·Dmitry V Ostanin, Dhruva Bhattacharya
Dec 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ainhoa ArinaHans Schreiber
May 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jane BryantXunrong Luo
Apr 12, 2016·Frontiers in Cellular and Infection Microbiology·Michael OstDominik Hartl
Feb 13, 2016·Annual Review of Biomedical Engineering·Timothy P PaderaLance L Munn
Apr 12, 2011·Journal of Surgical Oncology·Rongxiu Zheng, Suyu Shu
Apr 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yun-Sun KimChang-Yuil Kang
May 31, 2015·Cancer Immunology, Immunotherapy : CII·Mehrdad Talebian YazdiSjoerd H van der Burg
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Feb 21, 2013·Cellular and Molecular Life Sciences : CMLS·Janesh PillayLeo Koenderman
Mar 23, 2012·Nature Reviews. Immunology·Dmitry I GabrilovichVincenzo Bronte
May 1, 2012·Veterinary and Comparative Oncology·A M GuthS W Dow
Sep 29, 2012·Immunological Investigations·Ngozi R Monu, Alan B Frey
Mar 22, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Nancy P JuddRavindra Uppaluri
Mar 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Indu R RamachandranYulia Nefedova
Mar 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuki KatayamaFuminori Sakurai
Oct 17, 2019·Frontiers in Oncology·Gabriela Coeli Menezes EvangelistaJacy Gameiro
Jan 31, 2020·Frontiers in Immunology·Jennifer L HopePeter D Katsikis
Feb 15, 2011·International Journal of Experimental Pathology·Agnieszka Pastuła, Janusz Marcinkiewicz

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