Tumor-Induced Myeloid Cells Are Reduced by Gemcitabine-Loaded PAMAM Dendrimers Decorated with Anti-Flt1 Antibody

Molecular Pharmaceutics
Digdem Yoyen-ErmisGunes Esendagli

Abstract

While reshaping their microenvironment, tumors are also capable of influencing systemic processes including myeloid cell production. Therefore, the tumor-induced myeloid cells, such as myeloid-derived suppressor cells (MDSCs), which are characterized with pro-cancer properties, became another target in order to increase the success of the therapy. This study evaluated the capacity of a novel dendrimeric drug delivery platform to eliminate tumor-induced myeloid cells. As described in a previous study by our research group, the anti-Flt1 antibody-conjugated polyethylene glycol (PEG)-cored poly(amidoamine) (PAMAM) dendrimers improved the efficacy of gemcitabine against pancreatic cancer. Here, the biodistribution studies showed that these dendrimeric structures accumulated in the compartments that became rich in myeloid cells in the pancreatic tumor-bearing mice. When gemcitabine was loaded into the dendrimer complexes, the number of myeloid cells was significantly reduced while the percentage distribution of granulocytic and monocytic myeloid cells was not always significantly altered. The CD11b+Ly6G-Ly6C+ monocytes were more severely affected by the treatments than CD11b+Ly6G+Ly6C+ granulocytes. Immune infiltration levels in the...Continue Reading

References

Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B AlmandD I Gabrilovich
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mikhail M DikovDavid P Carbone
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eiji SuzukiSteven M Albelda
Jan 11, 2007·Cancer Research·Dmitry I GabrilovichHans Schreiber
Jan 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Masato MurakamiMasabumi Shibuya
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark B MeadsWilliam S Dalton
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevJohannes Vieweg
Jul 18, 2008·Cancer Research·Farbod Shojaei, Napoleone Ferrara
Sep 17, 2011·Clinical & Developmental Immunology·Shigeo KoidoHisao Tajiri
Jul 1, 2010·Journal of Natural Science, Biology, and Medicine·Husain Attarwala
Jan 1, 2010·Journal of Blood Medicine·Chang H Kim
Feb 19, 2013·Nature Immunology·Thomas A Wynn
May 20, 2014·Journal of Biochemistry·Ken Matsumoto, Masatsugu Ema
Nov 5, 2014·Journal of Pharmaceutical Sciences·Magdalena Labieniec-Watala, Cezary Watala
Mar 17, 2015·Trends in Immunology·Lee B Rivera, Gabriele Bergers
Jul 29, 2015·Advances in Cancer Research·Melanie R RutkowskiJose R Conejo-Garcia
Dec 15, 2015·Talanta·Elif Burcu Bahadır, Mustafa Kemal Sezgintürk
Mar 17, 2016·Journal for Immunotherapy of Cancer·Paul R KunkOsama E Rahma
Jul 7, 2016·Nature Communications·Vincenzo BronteDmitry I Gabrilovich
Jul 13, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoki HorikawaIkuo Konishi
Aug 19, 2016·Journal of Biomaterials Science. Polymer Edition·Mustafa U GürbüzMetin Tülü
Oct 21, 2016·Microbiology Spectrum·Kipp WeiskopfIrving L Weissman
Dec 15, 2016·International Journal of Pharmaceutics·Kıvılcım ÖztürkSema Çalış
Dec 15, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·George A DominguezDmitry I Gabrilovich

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Citations

Jan 12, 2019·Journal for Immunotherapy of Cancer·Claudia MaletzkiChristian Junghanss
Jan 30, 2020·Materials·Claudia Sandoval-Yañez, Cristian Castro Rodriguez
Dec 12, 2020·Acta Pharmaceutica Sinica. B·Yuefei ZhuZhiqing Pang
May 17, 2021·Colloids and Surfaces. B, Biointerfaces·Bhavya SurekhaPrashant Kesharwani
Dec 31, 2019·Molecular Immunology·Sean H ColliganScott I Abrams

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