Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

The Journal of Clinical Investigation
Stefano UgelVincenzo Bronte

Abstract

The generation of an inflammatory environment is favorable and often decisive for the growth of both primary tumors and metastases. Tumor cells either express membrane molecules or release tumor-derived soluble factors able to alter myelopoiesis. Tumor-reprogrammed myeloid cells not only create a tolerogenic environment by blocking T cell functions and proliferation, but also directly drive tumor growth by promoting cancer stemness, angiogenesis, stroma deposition, epithelial-to-mesenchymal transition, and metastasis formation. In this Review, we discuss the interplay between immunosuppressive and protumoral myeloid cells and detail their immune-regulatory mechanisms, the molecular pathways involved in their differentiation, as well as their potential role as prognostic and diagnostic biomarkers and prospective targets for innovative approaches to treat tumor-bearing hosts.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J A BennettM S Mitchell
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra MazzoniDavid M Segal
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·P'ng Loke, James P Allison
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah E MacphailJohn W Coleman
Apr 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joël LeMaoultEdgardo D Carosella
Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Aug 2, 2005·Nature Reviews. Immunology·Vincenzo Bronte, Paola Zanovello
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eiji SuzukiSteven M Albelda
Oct 4, 2006·The Journal of Clinical Investigation·Giovanna GallinaVincenzo Bronte
Mar 17, 2007·Cancer Research·Jeffrey B WyckoffJohn Condeelis
May 4, 2007·The Journal of Clinical Investigation·Antonio Sica, Vincenzo Bronte
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paola FilipazziLicia Rivoltini
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratima SinhaSuzanne Ostrand-Rosenberg
Aug 1, 2007·Nature Biotechnology·Farbod ShojaeiNapoleone Ferrara
Oct 3, 2007·Cancer Research·Carolyn E ClarkRobert H Vonderheide
Dec 8, 2007·Nature·Farbod ShojaeiNapoleone Ferrara
Jul 18, 2008·Nature Reviews. Cancer·Craig MurdochClaire E Lewis
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nigel D L SavageTom H M Ottenhoff
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratima SinhaGeetha Srikrishna
Sep 30, 2008·Nature Cell Biology·Sachie HiratsukaYoshiro Maru
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Je-In YounDmitry I Gabrilovich
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer S KoJames H Finke
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cesar A CorzoDmitry I Gabrilovich
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna MandruzzatoPaola Zanovello
Nov 27, 2009·European Journal of Immunology·Luigi DolcettiVincenzo Bronte
Dec 23, 2009·Current Cancer Drug Targets·H K Brown, I Holen

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Citations

Jul 6, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Scott I AbramsMichelle N Messmer
Dec 3, 2016·Cancer Gene Therapy·M Pergamo, G Miller
Dec 28, 2016·Cell Research·Rong-Fu Wang, Helen Y Wang
Dec 22, 2016·Immunology and Cell Biology·Kyohei Nakamura, Mark J Smyth
May 30, 2017·Current Opinion in Pharmacology·Giada MondanelliVincenzo Bronte
Jun 10, 2017·Molecular Oncology·Meggy Suarez-CarmonaChristine Gilles
Apr 7, 2017·Cancer Immunology, Immunotherapy : CII·Viktor UmanskyJochen Utikal
Mar 24, 2017·Journal for Immunotherapy of Cancer·David F StroncekBarbara Seliger
Jun 27, 2017·The Journal of Clinical Investigation·Mathieu F ChevalierLaurent Derré
Jun 16, 2017·Molecular Oncology·Akihiro KatsuraDaizo Koinuma
Feb 10, 2016·Trends in Immunology·Vinit KumarDmitry I Gabrilovich
Feb 4, 2016·Trends in Immunology·David H Munn, Andrew L Mellor
Jul 14, 2017·British Journal of Cancer·Tristan A Barnes, Eitan Amir
Mar 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yunhuan GaoRongcun Yang
Apr 25, 2018·International Journal of Molecular Sciences·Junko MasudaMasaharu Seno
Mar 31, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colleen S NetherbyScott I Abrams
Sep 26, 2017·The Journal of Clinical Investigation·Donatella De FeoGianvito Martino
Feb 14, 2018·The Journal of Experimental Medicine·Curtis J PerrySusan M Kaech
Jul 1, 2017·Journal of Cellular Physiology·Elham SafarzadehBehzad Baradaran
May 29, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jorgen KjaergaardMichail Sitkovsky
Jul 13, 2018·Cancer Science·Naohiro SeoHiroshi Shiku
Jul 7, 2016·Nature Communications·Vincenzo BronteDmitry I Gabrilovich
Sep 14, 2018·Journal for Immunotherapy of Cancer·Guozhu XieYawei Yuan
Oct 6, 2017·Science Translational Medicine·Matthias Pinter, Rakesh K Jain
Feb 28, 2019·Journal of Leukocyte Biology·Simone Cardozo StoneAna Paula Lepique
Nov 6, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Amin Pastaki KhoshbinNima Rezaei
Aug 23, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Chandan SangheraDavid J Pinato
Oct 1, 2019·The Journal of Clinical Investigation·Hemn MohammadpourElizabeth A Repasky
Nov 23, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Emilie Stavnsbjerg LarsenIsik Somuncu Johansen
Apr 25, 2020·Cancers·Veronica Mendoza-ReinosoPierrick G J Fournier
Aug 11, 2018·ESMO Open·Ana Luísa CoelhoAntónio Manuel Araújo

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