Tumor-infiltrating dendritic cells in cancer pathogenesis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jo Marie Tran JancoKeith L Knutson

Abstract

Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immune-stimulatory capacity.

References

Apr 1, 1998·Nature·J Banchereau, R M Steinman
Oct 31, 2001·Journal of Immunotherapy·Simone MocellinFrancesco Maria Marincola
Mar 27, 2002·Nature Reviews. Immunology·Ken Shortman, Yong-Jun Liu
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Apr 22, 2003·Nature Medicine·Tyler J CurielWeiping Zou
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yulia NefedovaDmitry Gabrilovich
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevDmitry I Gabrilovich
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong ZhengDavid M Sansom
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiichi SatoKunle Odunsi
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ivan PerrotSerge Lebecque
Sep 28, 2007·Nature·Ralph M Steinman, Jacques Banchereau
Dec 18, 2007·Current Opinion in Immunology·Bali PulendranTimothy L Denning
Dec 19, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danielle CanioniLuc Xerri
Mar 4, 2008·Cancer Immunology, Immunotherapy : CII·Patrizia StoitznerFranca Ronchese
Apr 22, 2008·Nature Immunology·Lewis L Lanier
Apr 22, 2008·Nature Immunology·Eric VivierSophie Ugolini
Jul 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Li WangRandolph J Noelle
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei ChenBruce R Blazar
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul SalamaBarry Iacopetta
Dec 17, 2008·Nature Reviews. Immunology·Facundo D Batista, Naomi E Harwood
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qiuyan LiuXuetao Cao
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Feb 6, 2010·Science·Frederic GeissmannKlaus Ley
Feb 3, 2011·Cancer Metastasis Reviews·Khashayarsha KhazaieDavid J Bentrem
Mar 26, 2011·The Journal of Clinical Investigation·Stephanie K WatkinsArthur A Hurwitz
Apr 14, 2011·Experimental Biology and Medicine·Caroline Jochems, Jeffrey Schlom
May 10, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·James KrempskiKeith L Knutson
Nov 30, 2011·PloS One·Adriana J MichielsenJacintha N O'Sullivan
Dec 23, 2011·Genes & Development·Stephen L ShiaoLisa M Coussens
Jan 10, 2012·Current Opinion in Immunology·Ana Carrizosa Anderson
Feb 22, 2012·The Journal of Experimental Medicine·Uciane K ScarlettJose R Conejo-Garcia
May 3, 2012·Cancer Research·Andrea FacciabeneGeorge Coukos
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jul 17, 2012·The American Journal of Pathology·Nina KarthausJurjen Tel

❮ Previous
Next ❯

Citations

Feb 26, 2016·Frontiers in Immunology·Susana Romero-GarciaFrancisco Javier Sánchez-García
May 4, 2016·Oncoimmunology·Silvana MorelloLuca Antonioli
Apr 12, 2016·Frontiers in Immunology·Yannick De VlaeminckKarine Breckpot
Aug 25, 2015·Cancer Immunology, Immunotherapy : CII·Keith L KnutsonEllen L Goode
Jun 1, 2016·Frontiers in Immunology·Adriana BonomoAlex Balduino
Nov 20, 2015·Journal of Immunology Research·Cleo Goyvaerts, Karine Breckpot
Mar 10, 2017·European Urology·Mathieu F ChevalierLaurent Derré
Mar 8, 2017·Seminars in Cancer Biology·Veronica HuberLicia Rivoltini
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Kun LiuLisa X Xu
Jun 7, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ana Carolina Amorim PellicioliPablo Agustin Vargas
Feb 10, 2016·Trends in Immunology·Vinit KumarDmitry I Gabrilovich
Mar 7, 2018·Endocrine-related Cancer·Kwon Joong Na, Hongyoon Choi
Dec 26, 2017·Frontiers in Immunology·Hassan SadozaiMirjam Schenk
Aug 18, 2018·International Journal of Molecular Sciences·Ya-Ling HsuPo-Lin Kuo
Aug 29, 2018·British Journal of Pharmacology·Debashree BasudharDavid A Wink
Oct 27, 2018·Annals of Surgical Oncology·Miao-Fen ChenWen-Cheng Chen
Apr 30, 2019·International Journal of Cancer. Journal International Du Cancer·Manuel StöthThomas Schmidt
Aug 17, 2018·Current Stem Cell Research & Therapy·Mahboobeh RazmkhahAbbas Ghaderi
Jul 12, 2019·Nature Reviews. Drug Discovery·Kevin HarringtonJean-Charles Soria
Jun 18, 2017·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·A BondocJ Yamate
Sep 26, 2019·Microbiology and Immunology·Chenglong MaChunjian Qi
Sep 11, 2019·International Journal of Molecular Sciences·Silvia Martina FerrariAlessandro Antonelli
Jan 15, 2020·Bulletin of Mathematical Biology·Avner Friedman, Nourridine Siewe
Jun 4, 2020·International Journal of Molecular Sciences·Annalisa Del PreteSilvano Sozzani
Nov 24, 2017·Acta Oncologica·Elisabeth Specht StovgaardEva Balslev
May 10, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P-P CaoZ Liu
Sep 3, 2020·International Journal of Cancer. Journal International Du Cancer·Yong ZhangYun Xiao
Jul 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lanlan LiuYifan Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.