Tumor-infiltrating lymphocytes and ductal carcinoma in situ of the breast: friends or foes?

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Marie Colombe AgahozoCarolien H M van Deurzen

Abstract

In the past three decades, the detection rate of ductal carcinoma in situ of the breast has dramatically increased due to breast screening programs. As a consequence, about 20% of all breast cancer cases are detected in this early in situ stage. Some ductal carcinoma in situ cases will progress to invasive breast cancer, while other cases are likely to have an indolent biological behavior. The presence of tumor-infiltrating lymphocytes is seen as a promising prognostic and predictive marker in invasive breast cancer, mainly in HER2-positive and triple-negative subtypes. Here, we summarize the current understanding regarding immune infiltrates in invasive breast cancer and highlight recent observations regarding the presence and potential clinical significance of such immune infiltrates in patients with ductal carcinoma in situ. The presence of tumor-infiltrating lymphocytes, their numbers, composition, and potential relationship with genomic status will be discussed. Finally, we propose that a combination of genetic and immune markers may better stratify ductal carcinoma in situ subtypes with respect to tumor evolution.

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Citations

Apr 25, 2019·International Journal of Cancer. Journal International Du Cancer·Mieke R Van BockstalCarolien H M van Deurzen
May 19, 2019·Clinical and Experimental Medicine·Guadalupe Avalos-NavarroAlicia Del Toro-Arreola
Jun 23, 2020·American Journal of Clinical Pathology·Mieke R Van BockstalChristine Galant
Apr 29, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marie Colombe AgahozoCarolien H M van Deurzen
Aug 4, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marie Colombe AgahozoCarolien H M van Deurzen
Jun 20, 2019·Frontiers in Pharmacology·Xin ZhaoDayong Cai
Jun 27, 2019·Annals of Surgical Oncology·Farbod DarvishianDaniel Roses
Feb 11, 2021·BioMed Research International·Jianjun LuYingling Zhou
Oct 3, 2018·The American Journal of Pathology·Bethany N Hannafon, Wei-Qun Ding

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Methods Mentioned

BETA
flow cytometry

Related Concepts

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Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

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