Tumor-infiltrating neutrophils predict benefit from adjuvant chemotherapy in patients with muscle invasive bladder cancer

Oncoimmunology
Lin ZhouJiejie Xu

Abstract

Growing evidence shows tumor-infiltrating neutrophils (TINs) involvement in tumorigenesis. The objective of this study is to assess the prognostic effect of TINs and its impact on adjuvant chemotherapy benefits in muscle invasive bladder cancer (MIBC). A total of 142 MIBC patients from Zhongshan Hospital, 119 MIBC patients from FUSCC, and 405 MIBC patients from TCGA cohort were enrolled in the study. TINs were evaluated by immunohistochemical staining of CD66b or the CIBERSORT method. Patients with high TINs had a significantly poorer overall survival (p = 0.001, p < 0.001, and p = 0.002, respectively) in the three sets. In the multivariate analysis, the presence of high TINs (HR = 2.122, p = 0.007; HR = 3.807, p < 0.001; HR = 2.104, p = 0.001; respectively) was identified as an independent prognostic factor for overall survival in the three sets. More importantly, Low TINs patients had significantly longer overall survival in patients without ACT in the three sets. Gene set enrichment analysis showed that lymphocyte activation (p < 0.001) and T cell activation (p = 0.008) were significantly enriched in the low TINs group. In addition, TINs were negatively correlated with CD8+ T cells, suggesting that the status of high-TINs wa...Continue Reading

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Citations

Dec 7, 2017·Oncoimmunology·Abhishek D GargLorenzo Galluzzi
Jun 29, 2018·PloS One·Maria Rosaria GaldieroGianni Marone
Sep 11, 2019·International Journal of Molecular Sciences·Silvia Martina FerrariAlessandro Antonelli
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Mar 9, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hangcheng FuJiejie Xu
Feb 18, 2021·Cell Transplantation·Jun LuJianming Tan
Mar 11, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Chengyun YaoHongping Xia

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS
edgeR
GSEA
R
CIBERSORT
Image Pro plus
Stata SE

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