PMID: 2383173May 1, 1990Paper

Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes, III: Evaluation of the mammary tumor inhibiting properties

Archiv der Pharmazie
H ReileJ Engel


Diastereomeric diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) sulfates and nitrates produce a strong inhibition of the hormone-dependent MXT-M 3.2 mammary carcinoma of the B6D2F1 mouse. Besides an interference in the DNA synthesis in analogy to cisplatin a lowering of the estrogen level due to an interference in steroid biosynthesis is suggested as the mode of action. In contrast to the R,R/S,S configurated diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) salts the corresponding R,S configurated compounds are also markedly active on the hormone-independent MXT-Ovex mammary carcinoma of the B6D2F1 mouse.


Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·M R SchneiderW P Brade
Dec 1, 1985·Journal of Medicinal Chemistry·M R SchneiderH Schönenberger
Sep 1, 1974·Journal of the National Cancer Institute·R CailleauW J Reeves

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Aug 8, 2009·Journal of Medicinal Chemistry·Anwen M Krause-HeuerJanice R Aldrich-Wright

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