Tumor location does not impact long-term survival in patients with operable thoracic esophageal squamous cell carcinoma in China

The Annals of Thoracic Surgery
Hao-Xian YangJian-Hua Fu

Abstract

The seventh edition of the American Joint Committee on Cancer staging system considers tumor location as a factor in staging esophageal squamous cell carcinoma (ESCC). However, more data are essential to test its efficacy. The purpose of this study is to assess whether tumor location should be included as a factor in staging of thoracic ESCC in Chinese patients. A retrospective review of 1,220 patients with ESCC who underwent complete resection between December 1996 and December 2008 was conducted. Survival was calculated by the Kaplan-Meier method, and the log-rank test was used to assess survival differences between groups. Subgroup analysis and the Cox proportional hazards model were used to further determine the impact of tumor location on overall survival. The median survival times for patients with ESCC in the upper third, middle third, and lower third of the esophagus were 45.1 months, 62.9 months, and 39.2 months, respectively, with corresponding 5-year survival rates of 44.8%, 50.5%, and 45.6%, respectively (p=0.191). Subgroup analysis also demonstrated that tumor location did not determine survival prognosis. Multivariate Cox regression analysis suggested that being female (p=0.001), being young (p<0.001), having a lo...Continue Reading

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Citations

Jan 23, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Qingyuan HuangJianhua Fu
May 28, 2013·The Annals of Thoracic Surgery·Hao-Xian Yang, Jian-Hua Fu
May 29, 2012·The Annals of Thoracic Surgery·Wayne L Hofstetter
Nov 25, 2014·Journal of Surgical Oncology·Qingyuan HuangJianhua Fu
Apr 23, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jian-Fei ZhuLan-Jun Zhang
Feb 11, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hui ShiLong-Qi Chen
Apr 17, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Thomas W RiceEugene H Blackstone
Sep 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yijun LuoMinghuan Li
Oct 26, 2013·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·S TakenoK Kawahara
Mar 15, 2018·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H-Y DengY-D Lin
Jun 16, 2015·The American Journal of Surgical Pathology·Agoston T AgostonAmitabh Srivastava
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Bai-Hua ZhangJie He

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