Tumor LXR Expression is a Prognostic Marker for Patients with Hepatocellular Carcinoma

Pathology Oncology Research : POR
Houyong LongQingxing Huang

Abstract

Liver X receptor (LXR) activation exerts an anti-tumor effect. However, whether the tumor LXR expression has prognostic significance in hepatocellular carcinoma (HCC) patient has not been addressed yet. Primary HCC and the adjacent non-tumor tissues were obtained from 169 patients who underwent routine curative surgical treatment. All patients were followed for prognosis analyses. Tumor LXR was detected by immunohistochemical analysis. In in vitro study, several HCC cell lines were cultured for cellular protein detection of LXR and other cytokines, including nuclear factor kappa (NFκB), Matrix metalloproteinases 2 and 9 (MMP-2 and -9). Meanwhile, the invasion ability of cultured HCC cell lines was performed. We found that LXR expression status in tumor samples is associated with the clinical characteristics, such as tumor stage and metastasis, of HCC patients. Prognosis analysis shows that tumor LXR expression status is closely related to the post-operative outcome in HCC patients who underwent surgical treatment. Patients with low LXR expression have a significantly lower mean 5-year overall survival rate and mean overall survival period than those with high LXR level. Our in vitro data reveal that HCC cell lines had increased...Continue Reading

References

Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Gianluigi GiannelliSalvatore Antonaci
Dec 24, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tae-Young NaMi-Ock Lee
Dec 3, 2010·Molecular and Cellular Biochemistry·Aanchal MehrotraKusum Joshi
Jul 21, 2011·Journal of Leukocyte Biology·Vincenzo Russo
Aug 22, 2013·Annals of Medicine·Marko LempinenHelena Isoniemi
Dec 31, 2014·World Journal of Gastroenterology : WJG·Bulent KaramanSamet Verim
Jun 9, 2015·World Journal of Hepatology·Kai-Wen ChenWu-Hsien Kuo
Mar 31, 2016·Molecular Biology Reports·Gang ZhaoFan Yan
Apr 9, 2016·World Journal of Hepatology·Jin Un KimSimon D Taylor-Robinson

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Citations

Jun 4, 2020·Cancers·Moris SanginetoGaetano Serviddio
May 20, 2019·Journal of Cellular Biochemistry·Xiaolong LiangZheng Xiang
Apr 26, 2019·Scientific Reports·K L Bowlt BlacklockM Starkey
Aug 6, 2019·Frontiers in Endocrinology·Urša KovačTadeja Režen
Jun 18, 2020·Frontiers in Oncology·Meiliang LiuXiaoyun Zeng
Mar 6, 2021·Life Sciences·Qiang WangHeng Zhang
Jun 5, 2021·Journal of Cancer Research and Clinical Oncology·Wanting ShaoSophie Sixou
Dec 15, 2020·Seminars in Cancer Biology·Joan Font-DíazAnnabel F Valledor

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Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

SPSS19

Related Concepts

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Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.